Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Rodríguez-Salgado, Ana M.a; b; 1 | Llibre-Guerra, Jorge J.a; b; c; *; 1 | Tsoy, Elenad | Peñalver-Guia, Ana Ibisa | Bringas, Giosmanya | Erlhoff, Sabrina J.d | Kramer, Joel H.b; d | Allen, Isabel Elainee | Valcour, Victorb; d | Miller, Bruce L.b; d | Llibre-Rodríguez, Juan J.f | Possin, Katherine L.b; d
Affiliations: [a] Department of Neurology, National Institute of Neurology and Neurosurgery, La Havana, Cuba. | [b] Global Brain Health Institute, University of California San Francisco, San Francisco, CA, USA. | [c] Department of Neurology, Washington University in St Louis, St Louis, MO, USA. | [d] Department of Neurology,Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA. | [e] Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA. | [f] Alzheimer Research Center, Havana School of Medicine, La Havana, Cuba.
Correspondence: [*] Correspondence to: Jorge J. Llibre Guerra, MD, MSc, Department of Neurology, National Institute of Neurology and Neurosurgery, 29 y D Vedado, La Havana, Cuba. E-mail: [email protected].
Note: [1] These authors contributed equally to this work.
Abstract: Background:Rapid technological advances offer a possibility to develop cost-effective digital cognitive assessment tools. However, it is unclear whether these measures are suitable for application in populations from Low and middle-income countries (LMIC). Objective:To examine the accuracy and validity of the Brain Health Assessment (BHA) in detecting cognitive impairment in a Cuban population. Methods:In this cross-sectional study, 146 participants (cognitively healthy = 53, mild cognitive impairment (MCI) = 46, dementia = 47) were recruited at primary care and tertiary clinics. The main outcomes included: accuracy of the BHA and the Montreal Cognitive Assessment (MoCA) in discriminating between controls and cognitively impaired groups (MCI and dementia) and correlations between the BHA subtests of memory, executive functions, and visuospatial skills and criterion-standard paper-and-pencil tests in the same domains. Results:The BHA had an AUC of 0.95 (95% CI: 0.91–0.98) in discriminating between controls and cognitively impaired groups (MCI and dementia, combined) with 0.91 sensitivity at 0.85 specificity. In discriminating between control and MCI groups only, the BHA tests had an AUC of 0.94 (95% CI: 0.90–0.99) with 0.71 sensitivity at 0.85 specificity. Performance was superior to the MoCA across all diagnostic groups. Concurrent and discriminant validity analyses showed moderate to strong correlations between the BHA tests and standard paper-and-pencil measures in the same domain and weak correlations with standard measures in unrelated domains. Conclusion:The BHA has excellent performance characteristics in detecting cognitive impairment including dementia and MCI in a Hispanic population in Cuba and outperformed the MoCA. These results support potential application of digital cognitive assessment for older adults in LMIC.
Keywords: Mild cognitive impairment, primary care, tablet-based cognitive screening
DOI: 10.3233/JAD-200985
Journal: Journal of Alzheimer's Disease, vol. 79, no. 1, pp. 85-94, 2021
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]