Affiliations: [a] Clinique Interdisciplinaire de Mémoire (CIME) du CHU de Québec, Québec, Canada
| [b] Department of Nuclear Medicine du CHU de Québec, Québec, Canada
| [c] Department of Nuclear Medicine, Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), Québec, Canada
| [d] Department of Nuclear Medicine, Montreal Neurological Institute (MNI), Montreal Neurological Institute, McGill University, Montreal, Canada | [e] Department of Neurology, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain
Correspondence:
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Correspondence to: David Bergeron, MD PhD candidate, Clinique Interdisciplinaire de Mémoire de l’Enfant-Jésus (CIME), CHU de Québec, Québec, Canada. Tel.: +1 581 995 5645; E-mail: [email protected].
Abstract: Background:Hypometabolism of the posterior cingulate cortex (PCC) is an important diagnostic feature of late-onset, amnestic Alzheimer’s disease (AD) measured with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). However, it is unclear whether PCC hypometabolism has diagnostic value in young-onset, non-amnestic variants of AD, which exhibit less pathology in the hippocampus and default mode network. Objective:Evaluate the prevalence and diagnostic value of PCC hypometabolism in non-amnestic variants of AD. Methods:We retrospectively identified 60 patients with young-onset, atypical dementia who have undergone a detailed clinical evaluation, FDG-PET, and an amyloid biomarker (amyloid-PET or cerebrospinal fluid analysis). We quantitatively analyzed regional hypometabolism in 70 regions of interest (ROI) using the MIMneuro® software. Results:Based on a cut-off of z-score < –1.5 for significant PCC hypometabolism, the prevalence of PCC hypometabolism in non-amnestic variants of AD was 65% compared to 28% in clinical variants of frontotemporal dementia (FTD). The ROI with the maximal hypometabolism was the dominant middle temporal gyrus in the language variant of AD (mean z score –2.28), middle occipital gyrus in PCA (–3.24), middle temporal gyrus in frontal AD (–2.70), and angular gyrus in corticobasal syndrome due to AD (–2.31). The PCC was not among the 10 most discriminant regions between non-amnestic variants of AD versus clinical variants of FTD. Conclusion:We conclude that PCC hypometabolism is not a discriminant feature to distinguish non-amnestic variants of AD from clinical variants of FTD—and should be interpreted with caution in patients with young-onset, non-amnestic dementia.
