Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer’s Disease

Article type: Research Article

Authors: Darst, Burcu F.^{a; 1; *} | Huo, Zhiguang^b | Jonaitis, Erin M.^c | Koscik, Rebecca L.^c | Clark, Lindsay R.^{c; d; e} | Lu, Qiongshi^f | Kremen, William S.^g | Franz, Carol E.^g | Rana, Brinda^g | Lyons, Michael J.^h | Hogan, Kirk J.^{c; i} | Zhao, Jinying^j | Johnson, Sterling C.^{c; d; e} | Engelman, Corinne D.^{a; c; e}

Affiliations: [a] Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA | [b] Department of Biostatistics, University of Florida, Gainesville, FL, USA | [c] Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA | [d] Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial VA Hospital, Madison, WI, USA | [e] Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA | [f] Department of Biostatistics & Medical Informatics, University of Wisconsin, Madison, WI, USA | [g] University of California, San Diego, La Jolla, CA, USA | [h] Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA | [i] Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA | [j] Department of Epidemiology, University of Florida, Gainesville, FL, USA

Correspondence: [*] Correspondence to: Burcu F. Darst, 1450 Biggy Street, 1517-F, Los Angeles, CA 90033, USA. Tel.: +1 323 442 0078; E-mail: [email protected].

Note: [1] Present address: Center for∥Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Keywords: Alzheimer’s disease, amino acids, cognition, executive function, fatty acids, longitudinal analysis, metabolomics

DOI: 10.3233/JAD-200176

Journal: Journal of Alzheimer's Disease, vol. Pre-press, no. Pre-press, pp. 1-14, 2020