Affiliations: [a] Radiation Oncology Department, Beaumont Health, Royal Oak, MI, USA
| [b] Beaumont Biobank, Beaumont Health, Royal Oak, MI, USA
| [c] Michigan Head and Spine Institute, Southfield, MI, USA
| [d] Department of Neurosurgery, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA
| [e] Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA
| [f] Radiation Oncology Institute, Division of Michigan Healthcare Professionals, Farmington Hills, MI, USA
Correspondence:
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Correspondence to: George D. Wilson, PhD, William Beaumont Hospital, Department of Radiation Oncology, 3811W Thirteen Mile Road, Royal Oak, MI 48073, USA. E-mail: [email protected].
Abstract: We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-β (Aβ) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice. Mice were hemibrain-irradiated with 5 fractions of 2 Gy and sacrificed 8 weeks after the end of treatment. Aβ and tau were assessed using immunohistochemistry and quantified using image analysis with Definiens Tissue Studio. We observed a significant reduction in Aβ plaque burden and tau staining; these two parameters were significantly correlated. This preliminary data is further support that low doses of radiation may be beneficial in Alzheimer’s disease.
