Affiliations: [a] School of Information Technologies, Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia
| [b] School of Science, Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia
| [c] Competence Center of Food and Fermentation Technology (TFTAK), Tallinn, Estonia
| [d] Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology, Eggenstein-Leopoldshafen, Germany
Correspondence:
[*]
Correspondence to: Raiker Witter, Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology,
Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany. Tel.: +372 586 087 74;
E-mail: [email protected].
Abstract: Fluorescence spectroscopy for in vitro amyloid-β (Aβ) fibrillation diagnosis and spectral fluorescence signature for the identification of bioactive compounds were applied to study traditional Ayurvedic nutraceuticals – Brahmi, Ashwagandha, Shanka pushpi, and Gotu kola – as well as their plant extracts for possible treatment of Alzheimer’s disease. All samples manifest as inhibitors on three different variants of the Aβ peptide: methionine Aβ1–40, Aβ1–40, and Aβ1–42. The main compounds within the nutraceuticals were identified. Since related medicals are known to have reduced negative post- and side-effects and even may introduce further positive health impacts by preventing pathogen plaque formation and reducing free Aβ to a natural level, such treatment approaches could be of further interest.
