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Article type: Research Article
Authors: Chanteloup, Gäetana; b; 1 | Cordonnier, Marinea; b; 1 | Moreno-Ramos, Teresac | Pytel, Vanesac | Matías-Guiu, Jorgec | Gobbo, Jessicad | Cabrera-Martín, María Nievese | Gómez-Pinedo, Ulisesc | Garrido, Carmena; b; d | Matías-Guiu, Jordi A.c; *
Affiliations: [a] INSERM, UMR1231, Labex LipSTIC, Dijon, France | [b] Université de Bourgogne-Franche Comté, Dijon, France | [c] Department of Neurology and Laboratory of Neurobiology, Hospital Clinico San Carlos, Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain | [d] Cancer Centre Georges François Leclerc, Dijon, France | [e] Department of Nuclear Medicine. Hospital Clinico San Carlos, Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain
Correspondence: [*] Correspondence to: Jordi A. Matías-Guiu, Department of Neurology, Hospital Clinico San Carlos, Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Prof. Martin Lagos s/n. 28040, Madrid, Spain. Tel.: +34913303511; +34676933312; E-mails: [email protected] and [email protected].
Note: [1] These authors contributed equally to this work.
Abstract: We aimed to study the expression of circulating heat-shock protein HSP70 and exosomes in plasma of a cohort of patients with Alzheimer’s disease (AD) and frontotemporal dementia (FTD) at different stages. We performed correlations with clinical scales and FDG-PET. HSP70 levels were higher within exosomes than free in plasma. Moderate correlations were found between exosomal HSP70 and CDR, FTLD-CDR, and extension of hypometabolism. Our results suggest modifications in the level of exosomal HSP70 during the course of neurodegeneration, regardless of AD or FTD, and therefore HSP70 could have a potential role in the follow-up of these disorders.
Keywords: Alzheimer’s disease, biomarkers, exosomes, frontotemporal dementia, PET
DOI: 10.3233/JAD-190545
Journal: Journal of Alzheimer's Disease, vol. 71, no. 4, pp. 1263-1269, 2019
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