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Article type: Research Article
Authors: Cui, Yuea | Dai, Sisia | Miao, Zupeia | Zhong, Yua | Liu, Yanga | Liu, Lina | Jing, Donglaia | Bai, Yanyana | Kong, Yua | Sun, Weia | Li, Fangb | Guo, Qihaoc | Rosa-Neto, Pedrod | Gauthier, Serged | Wu, Liyonga; e; *
Affiliations: [a] Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China | [b] Department of Geriatric, Fu Xing Hospital, Capital Medical University, Beijing, China | [c] Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China | [d] Alzheimer’s Disease Research Unit, McGill Centre for Studies in Aging, Verdun, QC, Canada | [e] National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing, China
Correspondence: [*] Correspondence to: Dr. Liyong Wu, Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China. Tel.: +86 13683120871; E-mail: [email protected].
Abstract: Background:The Mild Behavioral Impairment Checklist (MBI-C), a screening scale for neuropsychiatric symptom evaluation, facilitates Alzheimer’s disease (AD) screening. However, its validity and reliability for use as an AD screening tool have not been determined. Objective:To develop an AD screening scale suitable for the Chinese population. Methods:The MBI-C was translated into Chinese and back-translated with the original author’s consent. Forty-six AD patients, attending the Xuanwu hospital memory clinic, and 50 sex- and education-matched controls from the community underwent a full neuropsychological evaluation, including MBI-C assessment. Among them, 15 AD patients were evaluated repeatedly, and eight were evaluated simultaneously by two different clinicians, to assess MBI-C reliability. Results:The MBI-C demonstrated good internal consistency reliability, test–retest reliability, and inter-rater reliability. Its optimal cutoff point was 6/7 for identifying AD dementia, with a sensitivity of 86.96% and specificity of 86.00%, and its detection rate for moderate–severe AD dementia was higher than that of the Neuropsychiatric Inventory Questionnaire (NPI-Q). Pearson’s correlation coefficients ranged from 0.702 to 0.831, indicating content validity. Seven factors were extracted during principal component analysis, with a cumulative contribution of 70.55%. Moreover, the Pearson’s correlation coefficient was 0.758, indicating its criterion validity. The MBI-C could also distinguish AD dementia severity. MBI-C scores were significantly negatively correlated with MMSE and MoCA scores, and positively correlated with ADL scores. Conclusion:This study showed that the Chinese version of MBI-C has high reliability and validity, and could replace the NPI-Q for AD dementia screening in the Chinese population.
Keywords: Alzheimer’s disease, mild behavioral impairment checklist, neuropsychiatric inventory questionnaire, reliability, validity
DOI: 10.3233/JAD-190113
Journal: Journal of Alzheimer's Disease, vol. 70, no. 3, pp. 747-756, 2019
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