Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer’s Disease with Dementia

Article type: Short Communication

Authors: Alexopoulos, Panagiotis^{a; b; 1; *} | Thierjung, Nathalie^{a; 1} | Economou, Polychronis^c | Werle, Lukas^{a; d} | Buhl, Felix^a | Kagerbauer, Simone^e | Papanastasiou, Anastasios D.^f | Grimmer, Timo^a | Gourzis, Philippos^b | Berthele, Achim^g | Hemmer, Bernhard^{g; h} | Kübler, Hubertⁱ | Martin, Jan^e | Politis, Antonios^{j; k} | Perneczky, Robert^{h; l; m; n}

Affiliations: [a] Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany | [b] Department of Psychiatry, University Hospital of Rion, University of Patras, Patras, Greece | [c] Department of Civil Engineering (Statistics), University of Patras, Patras, Greece | [d] Max Planck Institute of Psychiatry, Munich, Germany | [e] Department of Anaesthesiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany | [f] Molecular Oncology Laboratory, Division of Oncology, University Hospital of Patras, University of Patras, Patras, Greece | [g] Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany | [h] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany | [i] Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany | [j] First Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece | [k] Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins Medical School, Baltimore, USA | [l] Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany | [m] Ageing Epidemiology (AGE) Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology and Medicine, London, UK | [n] German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

Correspondence: [*] Correspondence to: Dr. Panagiotis Alexopoulos, Department of Psychiatry, Faculty of Medicine, University Hospital of Rion, University of Patras, 26504 Rio, Patras, Greece. Tel.: +302613603728; Fax: +302610994534; E-mail: [email protected].

Note: [1] These authors contributed equally to this work.

Abstract: Cost- and time-effective markers of Alzheimer’s disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N = 33) are significantly lower (p < 0.01) than those of cognitively healthy elderly individuals without AD (N = 39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.

Keywords: Biomarker candidate, NIA-AA research framework diagnostic criteria, soluble amyloid-β protein precursor β

DOI: 10.3233/JAD-181088

Journal: Journal of Alzheimer's Disease, vol. 69, no. 1, pp. 83-90, 2019