Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

Article type: Short Communication

Authors: Koop-Nieuwelink, Carolien^a | Sedaghat, Sanaz^{a; b} | Mutlu, Unal^{a; c} | Licher, Silvan^a | Franco, Oscar H.^a | Ikram, M. Arfan^a | Geerlings, Mirjam I.^d | Ikram, M. Kamran^{a; e} | Bos, Daniel^{a; c; *}

Affiliations: [a] Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands | [b] Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA | [c] Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands | [d] Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands | [e] Department of Neurology, Erasmus MC, Rotterdam, The Netherlands

Correspondence: [*] Correspondence to: Daniel Bos, MD, PhD, Department of Radiology and Nuclear Medicine, Department of Epidemiology, Erasmus MC University Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. Tel.: +31 10 7043930; Fax: +31 10 7044657; E-mail: [email protected].

Abstract: Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.

Keywords: Dementia, epidemiology, glomerular filtration rate, kidney function, stroke

DOI: 10.3233/JAD-181086

Journal: Journal of Alzheimer's Disease, vol. 67, no. 3, pp. 821-826, 2019