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Social Isolation and Cognitive Function in Later Life: A Systematic Review and Meta-Analysis



There is some evidence to suggest that social isolation may be associated with poor cognitive function in later life. However, findings are inconsistent and there is wide variation in the measures used to assess social isolation.


We conducted a systematic review and meta-analysis to investigate the association between social isolation and cognitive function in later life.


A search for longitudinal studies assessing the relationship between aspects of social isolation (including social activity and social networks) and cognitive function (including global measures of cognition, memory, and executive function) was conducted in PsycInfo, CINAHL, PubMed, and AgeLine. A random effects meta-analysis was conducted to assess the overall association between measures of social isolation and cognitive function. Sub-analyses investigated the association between different aspects of social isolation and each of the measures of cognitive function.


Sixty-five articles were identified by the systematic review and 51 articles were included in the meta-analysis. Low levels of social isolation characterized by high engagement in social activity and large social networks were associated with better late-life cognitive function (r = 0.054, 95% CI: 0.043, 0.065). Sub-analyses suggested that the association between social isolation and measures of global cognitive function, memory, and executive function were similar and there was no difference according to gender or number of years follow-up.


Aspects of social isolation are associated with cognitive function in later life. There is wide variation in approaches to measuring social activity and social networks across studies which may contribute to inconsistencies in reported findings.


Cognitive aging refers to a process in which some decline in cognitive function is observed as a consequence of healthy aging [1, 2]. Cognitive aging is widely considered to be a normal part of healthy aging whereas clinically significant changes in cognitive function are not [3–5]. The trajectory of cognitive aging varies across older people. Some people experience major cognitive decline that may progress to dementia, whereas others experience subtle changes and minor cognitive impairment, consistent with cognitive aging [6–8]. In addition, decline in some cognitive domains, such as memory and executive function, tends to be more age-related whereas decline in other domains, such as language and general knowledge, tends to be less affected by aging [9–12].

In addition to differences in the trajectories of cognitive aging, it has been observed that some older people have considerable brain pathology without exhibiting concomitant declines in cognition [13–15]. Cognitive reserve theory accounts for this discrepancy and for variations in cognitive aging by proposing that individuals with greater cognitive reserve are able to optimize cognitive performance by recruiting differential brain networks or using alternative cognitive strategies when faced with pathology [16, 17]. Protective lifestyle factors have been identified that may contribute to increased cognitive reserve, such as physical exercise, education, occupational complexity, and engaging in cognitive activity [18–20]. As these lifestyle factors are modifiable, interventions aimed at reducing risk and enhancing modifiable protective factors may provide a basis to ameliorate poor cognitive function [21, 22]. Good social connections may also increase cognitive reserve and protect against declining cognitive function [23]. However, compared to other lifestyle factors, the association between social connections and cognitive function is less clear, with conflicting findings [24, 25].

There are several reasons why the association between social connections and late-life cognition may be less well understood. Firstly, studying social concepts is more complex than assessing lifestyle factors such as physical activity or smoking which may be more readily observable and easier to quantify objectively using a standardized approach [26, 27]. The nature of social connections is more challenging to specify and isolate; for example, social connectivity may occur during other activities that provide cognitive stimulation [28]. It is therefore difficult to determine which factors or combination of factors are most beneficial to cognitive health [28].

In addition, there is a wide range of concepts associated with social connections [29]. Some concepts focus on structural aspects, such as social networks, social isolation, and marital or living situation, whereas others, such as social support, are more related to functional aspects of social contexts, and yet others consider the appraisal of social situations and feelings of loneliness [30]. It can be difficult to isolate specific social concepts as all are likely to interact or contribute to an individual’s social context, yet each is conceptually distinct [31]. Although studies often aim to assess one specific social concept, many create measures that combine questions assessing a range of concepts. For example, one study created a measure of social isolation that classified participants as isolated who were living alone, were unmarried, and had low levels of social support [32]. This measure may not accurately reflect social isolation, as living alone and being unmarried do not necessarily mean an individual is isolated [31]. Likewise, although social support can be useful in determining level of social isolation, both concepts have distinct definitions. Social isolation is defined as having few social contacts and low engagement or integration within a wider community [33] whereas social support focuses more on the availability of social contacts on whom the individual can draw for support if required [34]. Therefore, the extent to which a measure assesses social isolation could be disputed. In addition, some studies aim to assess either social activity or social networks, but often create measures that assess both concepts and sometimes also include other social indicators, such as marital status or living situation [35–39], social support [40], or perceptions of feeling understood [41]. Indeed, measures described as assessing one particular concept may contain elements that assess other distinct social concepts. Therefore, measures may not assess social concepts in isolation which may account for between-study inconsistencies regarding the relationship between social connections and cognitive function [42].

Reverse causality is another methodological issue particularly for cross-sectional studies that assess the association between social connections and cognitive function [43]. The nature of social relationships often changes in later life [44, 45] and there is evidence to suggest that people who experience a decline in cognitive and physical health may be less able to maintain their social relationships [46–48]. Therefore, poor social relationships may be a consequence of cognitive decline rather than a cause [49–51]. The risk of reverse causation can be reduced by using longitudinal data, and studies with a longer interval between the baseline assessment of social measures and follow-up of cognitive function are more reliable for inferring the direction of causality [24, 25].

Several previous reviews have considered the relationship between various aspects of social connections and cognitive function, such as social networks [24], loneliness or perceived isolation [52, 53], social activity and engagement [54], marital status, social networks, and social support [25, 54–56]. Each of these reviews reports equivocal findings regarding the association between aspects of social connections and cognitive function from both cross-sectional and longitudinal studies. A recent review uniquely considered the methodological quality of studies, applied meta-analytic techniques, and also considered structural (social activity and size of social networks) and functional (social support, loneliness, and satisfaction with household members) aspects of social relationships [25]. No previous review has focused on social isolation and the association with cognitive function.

Social isolation is defined as a state in which an individual has a minimal number of social contacts and lacks engagement with others and the wider community [33]. Social isolation can be viewed as a continuum, with isolation and a high level of social participation as opposing extremes [57]. Therefore, social isolation can be captured by studies that assess social networks and social activity or engagement [33]. Being socially isolated may be associated with having fewer social contacts, a smaller social network [16, 43], and less engagement in social activity. In turn, this may be associated with fewer opportunities to make new social contacts, thus leading to a smaller social network and increased isolation [31]. From a cognitive reserve perspective, engaging with people in the social network and participating in social activity is cognitively effortful and hence may contribute to building cognitive reserve and enhancing cognitive function [24, 51].

Given that social isolation may be associated with poor cognitive function in later life, we aimed to investigate, through a systematic review and meta-analysis of data from longitudinal cohort studies, the relationship between aspects of social isolation (including social activity and social networks) and cognitive function in community-dwelling older people. We considered studies that assessed cognition using validated measures of global cognition, as these are frequently used, and measures of memory and executive function, as change in these domains is central to the concept of cognitive aging [9]. Finally, given the variation in approaches to measuring social isolation, we aimed to summarize methods used to assess this concept in articles identified by the review.


Systematic search strategy

To identify longitudinal articles assessing the relationship between aspects of social isolation and cognitive function in later life, a systematic search was conducted in PsycInfo, CINAHL, PubMed, and AgeLine for English-language publications to 11 October 2016. No date restrictions were imposed. Search terms focused on three areas: 1) aspects of social isolation (e.g, social relationships, social contact, social activity, social engagement), 2) cognitive function (e.g, cognition, cognitive decline, cognitive health), and 3) later life (e.g, older, aging). See Supplementary Table 1 for full details of the search terms. An identical, updated search was conducted in the same databases on 8 January 2018.

Table 1

Characteristics and results of studies included in the review

Population characteristicsMeasures
AuthorCountry, Study cohortStudy duration in yearsN in analysisAge, M (SD), range in yearsWomen (%)Social isolation measureCognitive measureStudy quality
Aartsen et al. [28]Netherlands, Longitudinal Aging Study Amsterdam6112668.7 (8.3), 55–8555Social activity: church attendance, neighborhood association, helping othersGlobal cognition: MMSE39
Ellwardt et al. [78]Mean: 6 Maximum: 20220167.7 (8.27), 54–8554Social network: social network size, number of social rolesGlobal cognition: MMSE40
Klaming et al. [79]Maximum: 14196676.2 (6.8), ≥6554Social activity: organization membership, leisure activityEpisodic memory: Rey Auditory Verbal Learning Test36
Albert et al. [66]*USA, Established Populations for Epidemiologic Studies of the ElderlyRange 2–2.5119274.3 (2.7), 70–7955Social network: number of contactsGlobal cognition: composite measure of language (Boston naming test), nonverbal and verbal memory (delayed recognition span test), conceptualization (similarities subtest of the WAIS-R), and visuospatial ability (figure copying)35
Bassuk et al. [112]12710NR, ≥6563Social network and activity combined: marital status, frequency of social contact, leisure activity, group membershipGlobal cognition: SPMSQ36
Béland et al. [67]*Spain, Aging in Legane’s651975.6 (6.9), 65–10058Social network: number of relatives, frequency of contact, living arrangementGlobal cognition: PCL41
Social activity: group membership, leisure activity
Zunzunegui et al. [51]4557NR, ≥6547Social network: number of contacts, frequency of contactGlobal cognition: composite measure of the SPMSQ, the Barcelona test, and short story recall40
Social activity: group membership, social and leisure activity
Bennett et al. [80]USA, Rush Memory and Aging ProjectNR8984.3 (5.6)55Social network: number of contacts, frequency of interactionGlobal cognition: composite measure of episodic memory (immediate and delayed recall, word list memory, recall, and recognition), semantic memory (Boston naming test, verbal fluency, reading test), working memory, (digit span forward and backward, digit ordering), perceptual speed (symbol digit modalities test, number comparison, Stroop test), and visuospatial ability (judgement line orientation and Raven’s standard progressive matrices).28
Boyle et al. [68]*Mean 4.0 (1.58) Range 1–769880.4 (7.4)7535
James et al. [72]*Mean: 4.5 Maximum: 895478.4 (NR), ≥557433
James et al. [81]Mean: 5.2 Range 0.4–12.3113879.6 (7.5), ≥6574Social activity: cultural and leisure activity35
Bielak et al. [82]Australia, Australian Longitudinal Study of AgeingMean: 5.8 Maximum: 15132177.46 (NR), 65–9849Social activity: group social activity, interaction with friends and familyImmediate episodic memory: Boston naming test Delayed episodic memory: Boston naming test39
Giles et al. [83]2Maximum: 1570678.6 (5.7), ≥7032Social network: number of contact, living arrangement, frequency of contact, existence of confidantEpisodic memory: recall test37
Brown et al. [92]1Canada, Victoria Longitudinal StudyMaximum 1897768.6 (6.7), 55–8563Social activity: leisure and cultural activity, volunteer work, visiting friends and relatives, organization membershipMemory: list learning and recall Executive function: similarities fluency task38
Brown et al. [69]*Maximum: 1875568.3 (7.0), NR6536
Small et al. [75]*Mean: 9.3 Maximum: 1295268.6 (6.7), 55–9463Episodic memory: word and story recall39
Semantic memory: fact recall and vocabulary
Ertel et al. [70]*USA, Health and Retirement Study61663864.5 (0.08), 51–9958Social network and activity combined: marital status, volunteer work, visiting friends, family, and neighborsMemory: immediate and delayed recall38
Nelson et al. [36]Maximum: 12203NR, ≥5059Memory: TICS-M35
Global cognition: TICS-Mental status
Glei et al. [84]Taiwan, Study of Health and Living Status of the Elderly in TaiwanMaximum: 7238771.8 (5.2), 64–9444Social network: marital status, number of contacts, frequency of contactGlobal cognition: SPMSQ39
Social activity: volunteer work, leisure activities, visiting friends and relatives, organization membership
Hsu et al. [71]63302NR, ≥6044Social activity: paid/unpaid work, organization membership, social clubGlobal cognition: SPMSQ35
Yen et al. [85]10114269.8 (4.9), ≥6459Social activity: volunteer work, participating in group activityGlobal cognition: SPMSQ37
Haslam et al. [86]UK, English Longitudinal Study of AgeingMaximum: 4341362.6 (8.9), 50–9957Social activity: relationship quality, frequency of contact, number of close contacts Social network: cultural and leisure activities, group membershipGlobal cognition: composite measure of orientation (orientation measure from MMSE), immediate and delayed memory (immediate and delayed verbal learning task), prospective memory (remembering to carry out a previous instruction), and verbal fluency (category recall)38
Shankar et al. [87]4603465.6 (9.5), ≥5055Social network and activity combined: marital status, frequency of contact with family and friends, organization membership, leisure activityMemory: immediate and delayed word recall Executive function: verbal fluency test40
Hill et al. [35]USA, Hispanic Established Populations for Epidemiologic Study of the Elderly8247272.3 (6.1), 65–10758Social network and activity combined: marital status, living arrangement, church attendance, frequency of contact with familyGlobal cognition: MMSE37
Howrey et al. [88]Maximum: 18276773.2 (6.5), ≥6558Social activity: church attendanceGlobal cognition: MMSE38
Li &Zhang [40]China, Chinese Longitudinal Healthy Longevity Survey7419077.6 (9.4), 64–11454Social network and activity combined: marital status, number of close children, social support, leisure activity, social groupsGlobal cognition: MMSE39
Zhang [77]*2386783.8, 90–10559Social network: marital status, number of children who visit regularlyGlobal cognition: MMSE38
Marioni et al. [74]*France, PAQUIDMaximum: 20365375.3 (6.8), ≥6558Social activity: group membership, visits from family and friendsGlobal cognition: MMSE38
Marioni et al. [73]*Maximum: 20285477.0 (6.8)59Social network: number of contactsGlobal cognition: MMSE40
Stoykova et al. [41]Mean: 9.2 (6.6) Maximum: 20205274.6 (6.66), ≥6554Social network: number of contacts, satisfaction with relationships, social group membershipGlobal cognition: MMSE40
McHugh Power et al. [89]Ireland, Irish Longitudinal Study of Ageing2698563.5 (9.5), 50–8054Social activity: social and leisure activitiesGlobal cognition: composite measure of immediate and delayed recall and MMSE37
Santini et al. [38]Median: 2 years Range: 16–40 months60986.3 (9.2), ≥5052Social network and activity combined: marital status, number of contacts, frequency of contact, church attendance, group membershipGlobal cognition: MMSE39
Niti et al. [90]Singapore, Singapore Longitudinal Aging StudiesMedian: 1.5 Range 1-2163566.0 (7.3), 55–9365Social activity: cultural and leisure activitiesGlobal cognition: MMSE39
Schwingel et al. [91]21754NR, ≥55NRSocial activity: volunteering/paid workGlobal cognition: MMSE39
Thomas et al. [96]USA, American Changing Lives Survey31642Men: 69.4, 60–92 Women: 70.4, 60–9567Social activity: frequency of social contact, volunteer work, group membership, church attendanceGlobal cognition: SPMSQ39
Thomas et al. [76]*Maximum: 16 Average: 2.6166770.1 (NR), ≥6067Global cognition: SPMSQ37
Barnes et al. [111]USA, Chicago Health and Aging ProjectMean: 5.3 Maximum: 6389973.9 (6.5), ≥6562Social network: number of contacts, frequency of contactGlobal cognition: composite measure of episodic memory (immediate and delayed recall), perceptual speed (symbol digit modalities test), and the MMSE40
Social activity: cultural and leisure activities, paid/ volunteer work
Barnes et al. [99]USA, Study of Osteoporotic FracturesMaximum: 15970471.7 (5.3), 65–99100Social network: Lubben Social Network Scale (LSNS)Global cognition: Modified MMSE37
Bosma et al. [100]Netherlands, Longitudinal Maastricht Aging Study3818NR, 49–81NRSocial activity: organizational membershipGlobal cognition: MMSE40
Bourassa [93]Europe**, Survey of Health, Ageing, and Retirement in Europe61983264.4 (10.0), ≥5054Social activity: volunteer work, leisure activity, group membershipMemory: immediate and delayed word recall Executive function: category fluency task40
Brown et al. [92]1Sweden, Origins of Variance in the Oldest-Old (OCTO)Maximum: 852483.2 (2.9), ≥8066Social activity: number of social contactsMemory: immediate recall38
USA, Long Beach Longitudinal StudyMaximum: 956573.8 (9.1), ≥5549Social activity: frequency of social contact, volunteer work, leisure activity, visiting friends and familyMemory: immediate recall
USA, Seattle Longitudinal StudyMaximum 21165767.1 (8.2), ≥5552Executive function: word fluency test
Gallucci et al. [101]Italy, Treviso Longeva730979.1 (9.7), 70–10560Social activity: visiting friends, volunteer work, social groupsGlobal cognition: MMSE37
Ghisletta et al. [113]Switzerland, Swiss Interdisciplinary Longitudinal Study on the Oldest Old552983.4 (2.6), 80–8552Social activity: cultural and leisure activitiesGlobal cognition: composite measure of executive function (category fluency test) and perceptual speed (cross-out test)37
Ho et al. [94]China, Sample of Chinese elderly3Men: 519 Women: 46977.4 (5.99), ≥7047Social network and activity combined: contact with friends, relatives, neighbors, religious attendance, community groupsGlobal cognition: composite measure of the Clifton Assessment Procedure for the Elderly, MMSE, and the Mental Status Questionnaire40
Holtzman et al. [118]USA, Epidemiologic Catchment Area survey, BaltimoreMean: 12.4 Maximum: 1534161.3 (6.9), 50–8169Social network: living arrangement, frequency of contactGlobal cognition: MMSE41
Hughes et al. [116]USA, Charlotte County Healthy Aging StudyMean: 4.9 Range 4.6–5.321772.4 (6.2), ≥6552Social network: frequency of social contact, number of contactsGlobal cognition: Modified MMSE Memory40
Iwasa et al. [102]Japan, Otasha-Kenshin556775.8 (3.5), 70–8450Social activity: volunteer work, group social activitiesGlobal cognition: MMSE41
Jedrziewski et al. [105]USA, National Long Term Care Survey10927NR, ≥6565Social activity: frequency of social contact, organization membership, religious attendanceGlobal cognition: SPMSQ40
Kareholt et al. [106]Sweden, Random samples of the Swedish populationMean: 22.8 Range: 21–24164357.4 (NR), 46–8559Social activity: visiting/being visited by friends and relativesGlobal cognition: MMSE40
Katja et al. [95]Finland, Evergreen Project211181NR, 65–8466Social activity: cultural and leisure activities, organization membership, volunteer workGlobal cognition: Mini-D38
Lee et al. [107]South Korea, Suwon Longitudinal Aging Study297773.0 (5.7), ≥6561Social activity: frequency of social contact, leisure and cultural activityGlobal cognition: MMSE40
Lee &Kim [103]Korea, Korean Longitudinal Study of Aging4156871.06 (0.12) ≥6546Social activity: organization membership, religious attendance Social network: frequency of social contactGlobal cognition: MMSE40
Leung et al. [64]*China, Population based community survey of Hong Kong Chinese22 months50574.5 (7.1), 61–10055Social activity: volunteer work, cultural and leisure activityGlobal cognition: MMSE35
Li &Hsu [98]2Taiwan, Taiwan Longitudinal Study of Aging4322662.7 (9.6), ≥6554Social activity: volunteer/paid work, organization/group membershipGlobal cognition: SPMSQ38
McGue &Christensen [108]Denmark, Longitudinal Study of Aging Danish TwinsMaximum: 87075.7 (5.2), ≥7563Social activity: leisure activity, visiting or being visited by friends and familyGlobal cognition: MMSE Global cognition: composite measure of executive function (verbal fluency), working memory (forward and backward digit span) and memory (immediate and delayed recall)39
McHugh Power et al. [117]Ireland, Community dwelling Irish262472 (6.8), 60–8968Social network: Lubben Social Network Scale (LSNS)Global cognition: MMSE39
Monastero et al. [115]Sweden, Kungsholmen ProjectMean: 3.471880.4, 75–9574Social activity: leisure activityGlobal cognition: MMSE39
Social network: number of contacts
Mousavi-Nasab et al. [109]Sweden, Betula Project579474.1 (7.1), 65–8555Social activity: visiting family and friends, cultural and leisure activityEpisodic memory: free and cued recall and recognition Semantic memory: vocabulary and verbal fluency38
Obisesan &Gillum [37]USA, The Third National Health and Nutrition Examination SurveyMean: 8.5 Range: 6–125908NR, ≥60NRSocial network and activity combined: marital status, frequency of social contact, religious attendance, volunteer wokGlobal cognition: Short Index of Cognitive Function38
Plehn et al. [65]*USA, Community dwelling VirginiaMean: 3.6 Range: 3.2–4.39675.6 (7.9), ≥5578Social activity: social subscale from the SELF-scaleGlobal cognition: composite measure of Mattis Dementia Rating Scale, Fuld object memory evaluation, and MMSE37
Seeman et al. [114]USA, McArthur Studies of Successful AgingMean 7.470674.2, 70–7955Social activity: marital status, number of social contacts Social network: social group membershipGlobal cognition: composite measure of language (Boston naming test), abstraction (similarities subtest of the WAIS-R), spatial ability (copying), delayed spatial recognition, immediate and delayed story recall38
Shatenstein et al. [104]Canada, Nutrition and Cognition Study3120874.2, 67–8453Social activity: cultural and leisure activity, community groupsGlobal cognition: 3MS40
Tomioka et al. [97]Japan, Community dwelling Japanese3609372.8, 65–9655Social activity: leisure activity, volunteer work, social groups, organization membershipGlobal cognition: Cognitive Performance Scale41
Van Ness &Kasl [39]USA, Yale Health and Aging Project6124574.6 (6.9), ≥6558Social network and activity combined: marital status, frequency of contact with family and friends, social groupsGlobal cognition: SPMSQ36
Wang et al. [110]China, Sample of Chinese elderly peopleMean: 4.7 Maximum: 5543763.4 (NR), ≥5551Social activity: visiting friends and familyGlobal cognition: MMSE39
Wang et al. [50]China, Longitudinal population-based study of ChineseMean: 2.4 Range: 2.3–2.6146371.0 (5.0), ≥6549Social activity: visiting or being visited by friends and family, giving adviceGlobal cognition: CSID Episodic memory: word list learning and recall, and story recall Executive function: token test40

NR, not reported; MMSE, Mini-Mental State Examination; WAIS-R, Wechsler Adult Intelligence Scale-Revised; SPMSQ, Short Portable Mental Status Questionnaire; PCL, Leganés’ Cognitive Test (Prueba Cognitiva de Leganés); TICS-M, Modified Telephone Interview for Cognitive Status – Memory; TICS-Mental status, Modified Telephone Interview for Cognitive Status – Mental status; CSID, Community Screening Instrument for Dementia; AD, Alzheimer’s Disease. 1This study reports data for four different cohorts: Origins of Variance in the Oldest-Old, Long Beach Longitudinal Study Participants, Seattle Longitudinal Study, and Victoria Longitudinal Study. 2Data for the total sample is reported in all meta-analyses except for the sub-analysis on gender where data for men and women are reported separately. *Data not reported in the meta-analysis. **Austria, Belgium, Czech Republic, Denmark, France, Germany, Greece, Italy, Netherlands, Poland, Sweden, Spain, and Switzerland.

Inclusion criteria

Articles were included if 1) the sample comprised people who were community-dwelling, ≥50 years at baseline, and with no cognitive impairment, 2) measured social isolation in terms of social network/contact and/or social engagement/activity, 3) measured cognitive function, decline, or change using a standardized measure of global cognitive function, memory, or executive function, 4) longitudinal with a minimum of one-year follow-up, providing an assessment of the relationship between social isolation and cognitive outcomes at follow-up, and 5) peer reviewed. Articles that assessed dementia status as an outcome were excluded as they related to dementia diagnosis rather than cognitive function.


A flowchart showing how articles were identified is presented in Fig. 1 and includes articles detected in the searches. Titles, abstracts, and full-text articles were screened by two independent reviewers (IEME and RC). Disagreements were resolved in consensus meetings or resolved by reference to a third reviewer (LC). Reference lists of included articles and relevant reviews [24, 25, 52, 54–56] were screened to identify additional articles that were not retrieved in the initial searches. Data extraction included information about study population, assessment of social isolation and cognitive function, statistical methods, and results.


Screening process for including articles.

Screening process for including articles.

The methodological quality of included articles was assessed by a single reviewer (IEME) based on the Critical Appraisal Skills Programme checklist for cohort studies and published guidelines [58]. The checklist comprised 14 items covering the following areas: study aims, population, method, measures, results, and analysis (see Supplementary Material 2). Each article received a score ranging from 1 (poor) to 3 (very good) for each item. Scores were summed to provide an overall quality rating for each article. Possible scores range from 14–42 with higher scores indicating greater methodological quality.

Statistical analysis

To investigate the association between social isolation and cognitive function a correlational random effects meta-analysis was conducted using Comprehensive Meta-Analysis 2 [59]. A standardized correlation direction was used, and where necessary the direction was changed to facilitate cross-study comparisons. For articles where r was not reported, data were transformed into r. For articles that reported a specific p value with standardized or unstandardized coefficients, or odds or hazard ratios, the p value was used. For articles that reported unstandardized coefficients, but without reporting a specific p value (e.g, reported p < 0.05), the precise p value was calculated using the formula suggested by Altman and Bland [60]. Articles that reported standardized coefficients were converted into r using the formula suggested by Peterson and Brown [61]. For articles that reported odds or hazard ratios, but did not report a specific p value, an exact p value was calculated using the formula suggested by Altman and Bland [60]. For articles that used latent growth curve models, or made comparisons across groups (e.g, ANCOVA), specific p values reported in the article for these analyses were used. Where p values were given as a range of significance a cautious approach was used in which the value used to calculate the correlation was set at the upper limit of the range (e.g, for p < 0.05 the value was set at p = 0.049). Where exact non-significant p values were not given and there was insufficient information to calculate a p value, r was reported as 0.

Where multiple articles used data from the same cohort and reported findings based on the same social or cognitive measure, the data included in the meta-analysis were selected based on the following hierarchical criteria: 1) data could be extracted for meta-analysis, 2) articles with the most comprehensive measures of social isolation, 3) longest follow-up duration, and 4) largest sample size. The software package was instructed to average the multiple within-article correlations to correct for violations of independence so that all available data could be included in the analysis.

Effect sizes were calculated using the random effects model as the included articles employed different methods of assessing social isolation and cognitive function and included heterogeneous samples of older people. The random effects model estimates and incorporates the magnitude of heterogeneity into the overall estimated effect [62]. Between-article heterogeneity was assessed using an index of inconsistency (I2) [63]. This calculates a percentage of heterogeneity resulting from study differences that is not due to chance; therefore, larger values indicate greater heterogeneity.

Articles identified in the search were grouped based on social measures as assessing either social activity, social networks, or a combination of both, based on how the authors of each article described the social measure assessed. Cognitive measures were grouped as assessing either global cognitive function, memory, or executive function. Several analyses were conducted to assess the relationships between aspects of social isolation and cognition as follows:

  • (a) All social measures and 1) all cognitive measures, 2) measures of global cognition, 3) memory, and 4) executive function.

  • (b) Social activity and 1) all cognitive measures, 2) measures of global cognition, 3) memory, and 4) executive function.

  • (c) Social networks and 1) all cognitive measures, 2) measures of global cognition, and 3) memory.

  • (d) Measures that assess a combination of social activity and networks and 1) all cognitive measures, 2) measures of global cognition, and 3) memory.

Two further sub-analyses were conducted that considered all social and cognitive measures and assessed:

  • (e) Gender differences where articles reported findings for men and women separately.

  • (f) Length of follow-up, divided into 2-3 years, 4–9 years, and 10–24 years follow-up.

We conducted further sub-analyses to assess how specific indicators of social activity and social networks were associated with cognitive function. Finally, we conducted sub-analyses to assess the association between measures of social activity/social networks and specific measures of cognitive function (e.g, the Mini-Mental State Examination: MMSE).


Identification of articles

The search identified 10,384 unique records, of which 621 abstracts were screened, and 208 full-text articles were examined, resulting in 65 articles meeting inclusion for the review. Table 1 summarizes characteristics of each article. Fifty-one articles were included in the meta-analysis.

Excluded articles

Fourteen articles were excluded from the meta-analysis for the following reasons: two articles contained no useable data [64, 65] and twelve articles were based on the same study populations and used the same social and cognitive measures included elsewhere in the review [66–77].

Included articles

Of the 51 articles included in the meta-analysis, seventeen were combined to create eight cohorts of participants as they included the same participants but reported different social and/or cognitive measures as follows: Longitudinal Aging Study Amsterdam [28, 78, 79], Rush Memory and Aging Project [80, 81], Australian Longitudinal Study of Ageing [82, 83], Study of Health and Living Status of the Elderly in Taiwan [84, 85], English Longitudinal Study of Ageing [86, 87], Hispanic Established Populations for Epidemiologic Study of the Elderly [35, 88], Irish Longitudinal Study of Ageing [38, 89], and Singapore Longitudinal Aging Studies [90, 91]. One article reported findings from four cohorts separately [92] and each cohort was included separately in the meta-analysis. One article [93] split and analyzed the sample into two distinct groups so each group was included as an individual study for the purposes of the meta-analysis. Five articles [51, 94–97] reported results for men and women separately. Two articles reported data for men and women together and separately [83, 98]; therefore, combined data were reported in the main analyses while separate data for men and women was included in the gender sub-analysis. One article reported findings for women only [99] and so was included in main analyses and sub-analyses for gender.

Fifty-one cohorts were included in the meta-analysis with a combined sample of 102,035 unique participants. Thirty-four articles assessed social isolation based on social activity or engagement, 15 assessed isolation based on social networks, and 9 articles assessed isolation based on a combination of both social activity and social networks. The duration of follow-up ranged from 2 to 24 years and the sample size of cohorts ranged from 70 to 19,832 participants (Table 1).

Association between social isolation and cognitive function

There was a statistically significant association between social isolation (i.e, social activity and social networks) and cognitive function, although the effect size was small and there was a moderate degree of heterogeneity (Table 2, Fig. 2). When considering specific measures of cognition, social measures were most strongly associated with measures of global cognition, followed by measures of memory, and then executive function. Effect sizes were small and statistically significant but there was considerable heterogeneity for global measures and tests of memory.


Forest plot of the positive association between social measures and cognitive measures, and differences between men and women, and number of years follow-up.

Forest plot of the positive association between social measures and cognitive measures, and differences between men and women, and number of years follow-up.
Table 2

Random effects meta-analysis and sub-analyses for aspects of social isolation and cognitive function

nkr95% CIpHeterogeneity
QQ pI2
All social measures
  All cognitive measuresa,b,c102,035510.0540.043, 0.065<0.001121.46<0.00158.86
  Global measuresa,b74,933430.0610.044, 0.079<0.001198.12<0.00178.80
  Memory c35,230130.0500.028, 0.072<0.00133.81<0.00164.51
  Executive function30,52870.0310.015, 0.047<0.0019.220.16134.95
Social activity
  All cognitive measuresa,b,c77,954390.0700.050, 0.089<0.001244.89<0.00184.48
  Global measuresa,b51,804310.0720.048, 0.095<0.001194.68<0.00184.59
  Memoryc29,099100.0490.023, 0.075<0.00131.46<0.00171.39
  Executive function24,49460.0320.011, 0.0520.0029.170.10345.47
Social network
  All cognitive measuresa30,037170.0720.032, 0.112<0.001156.41<0.00189.77
  Global measuresa29,684160.0670.026, 0.108<0.001151.95<0.00190.13
  Memory57020.107–0.041, 0.2500.1562.990.08466.51
  Executive function
Combination of social activity and social networks
  All cognitive measures23,783100.0360.024, 0.049<0.0017.320.6040.00
  Global measures17,74990.0360.020, 0.052<0.0018.520.3856.05
  Memory6,23720.0460.021, 0.070<0.0010.160.6930.00
  Executive function
All social measures and all cognitive measures
  Men6,44870.0480.021, 0.074<0.0016.490.3717.48
  Women17,64980.0590.028, 0.090<0.00118.340.01161.83
Follow-up time
  2-3 yearsb39,328160.0460.030, 0.062<0.00129.410.01449.00
  4–9 yearsa,c35,374210.0580.036, 0.080<0.00165.86<0.00169.63
  10–24 years33,393170.0590.039, 0.078<0.00140.09<0.00160.09

Note: Removing aHaslam et al. [86], bMcHugh Power et al. [89], and cBrown et al OCTO [92] reduced I2 and the effect size r (see Supplementary Material 3 for details).

Engagement in social activity and cognitive function

Thirty-nine cohorts assessed the relationship between social activity and cognitive function (Table 2, Fig. 2). Results suggest that engaging in social activity is significantly associated with better cognitive outcomes on all cognitive measures. When considering each type of cognitive measure separately, social activity was most strongly associated with better cognitive outcomes on global measures of cognition, followed by memory and executive function. Effect sizes were small and statistically significant but there was considerable heterogeneity except for tests of executive function.

Social networks and cognitive function

The association between social networks and cognitive function was assessed in 17 cohorts of participants (Table 2, Fig. 2). The meta-analysis found that larger social networks were significantly associated with better cognitive function when all cognitive measures were combined. This relationship was similar when considering global measures of cognition. Effect sizes were small and statistically significant but with considerable heterogeneity. When measures of memory were considered separately there was no significant association with social networks. While the effect size for the association between social networks and memory was marginally larger than for global measures there were only two cohorts included so this should be treated with some caution, particularly as there was a moderate degree of heterogeneity.

Combination of social activity and social networks and cognitive function

Ten cohorts included measures that assessed both social activity and social networks and the relationship with cognition (Table 2, Fig. 2). The associations between these combined social measures and all measures of cognitive function were statistically significant. The association with global measures was the same as the overall association, and similar for memory. Effect sizes were small and statistically significant, and there was little heterogeneity, suggesting that the effect sizes may be reliable. However, there were only two cohorts included in the memory comparison.

Effect of gender

We next investigated the relationship between social isolation and cognitive function in cohorts that report data for men and women separately. The effect of larger social relationships was similar for men and women. Effect sizes were small and statistically significant with a slight advantage for women (Table 2, Fig. 2), though there was considerably more heterogeneity for women than men.

Effect of follow-up time

Finally, we investigated the association between social isolation and cognitive outcomes over different follow-up times (Table 2, Fig. 2). Effect sizes for each time point were small, statistically significant, but with moderate heterogeneity. Effect sizes were slightly larger for cohorts with a 4–9-and 10–24-year follow-up compared to cohorts with a shorter follow-up of 2-3 years.

Methods of assessing social isolation

The different approaches to assessing social isolation in all articles identified by the systematic review (N = 65) are summarized below. Some indicators of social activity and social networks overlap and were used to assess both concepts.

Social activity/engagement

Fifty-two articles identified by the systematic review assessed social activity. Each of the articles assessed social activity using different indicators of social activity and many articles used more than one indicator within the measure. Twenty-seven articles assessed social and community activities such as attending social or senior citizen clubs, engagement in neighborhood associations, political organizations, and other community groups [28, 39, 41, 51, 64, 67, 71, 74, 79, 81, 82, 84–87, 90, 93–98, 100–104], 21 assessed frequency of visits from or to family, friends, and neighbors [50, 51, 64, 69, 74, 75, 81, 82, 84, 86, 92, 94, 96, 101, 103, 105–110], 23 assessed participation in voluntary or paid work [28, 36–38, 50, 64, 69–71, 81, 84, 85, 91–93, 95–98, 101, 102, 111, 112], and 36 assessed participation in cultural and leisure activities, such as attendance at religious organizations, participating in sport, attending the theatre, museums, exhibitions, eating at restaurants, travelling and overnight trips, attendance to parties, playing games, engaging in hobbies, and reading [28, 35, 37, 38, 40, 51, 64, 67, 69, 71, 75, 79, 81, 84, 86–90, 92–98, 103–105, 107–111, 113, 114]. Ten articles asked about engagement in groups or clubs generally and did not specify the type of groups [38, 40, 69, 71, 92, 105, 111, 112, 114, 115].

Social networks

Twenty-seven articles in the systematic review assessed social networks. Various indicators were used to assess social networks and were included in different combinations within measures across articles. Eighteen articles assessed the number of people within the social network, often using a count of the number of people in the social network [40, 41, 51, 66–68, 72, 73, 78, 80, 83, 84, 99, 111, 114–118], 19 assessed the frequency of interaction with social contacts [35–39, 51, 67, 68, 70, 72, 77, 80, 83, 84, 87, 99, 112, 116–118], 12 assessed marital status [35–40, 70, 77, 84, 87, 112, 114], 3 assessed living arrangements [35, 67, 83], and 3 assessed additional indicators such as satisfaction with social relationships, perception of feeling understood by others, and how many people the participant felt close to [41, 77, 83].

Association between specific indicators of social activity or social networks and cognitive function

Further sub-analyses were conducted to determine whether the different indicators of social activity and social networks could explain heterogeneity or were more associated with measures of cognitive function. There was not enough data to investigate the effects of different social indicators on global cognitive function, memory, and executive function separately, hence we considered the association between specific social indicators and all measures of cognitive function combined. Few articles reported findings for specific indicators separately but where possible sub-analyses were conducted. Social and community activities were described in nine articles [28, 51, 79, 82, 85, 97, 100, 103, 104], frequency of visits from or to, family, friends, and neighbors were described in seven articles [50, 51, 82, 86, 92, 103, 106], voluntary or paid work was described in six articles [28, 85, 91, 95, 97, 98], cultural and leisure activities were described in 12 articles [28, 51, 79, 86, 88–90, 95, 97, 103, 113, 114], social network size was described in six articles [51, 78, 111, 114, 115, 118], and marital status was described in two articles [84, 114]. Heterogeneity was considerably reduced for social and community activities, voluntary or paid work, social network size, and marital status, but remained high for frequency of visits from or to, family, friends, and neighbors, and cultural and leisure activities (Table 3).

Table 3

Random effects sub-analyses for specific indicators of social activity and social network and all measures of cognitive function

nkr95% CIpHeterogeneity
QQ pI2
Social activity
  Social and community activities13,903100.0370.020, 0.054<0.0017.790.5550.00
  Frequency of visits from or to family, friends, and neighbors10,48980.0740.029, 0.120<0.00133.42<0.00179.06
  Voluntary or paid work14,52280.0430.024, 0.062<0.0018.720.27319.72
  Cultural and leisure activities27,120140.0900.028, 0.1510.005317.48<0.00195.91
Social network
  Social network size7,71660.0480.022, 0.074<0.0015.750.33213.00
  Frequency of interaction with social contacts
  Marital status3,09320.015–0.021, 0.0500.4130.080.7740.00
  Living arrangements and proximity to other family

Methods of assessing cognitive function

Cognitive function was mostly assessed using measures of global cognitive function. The MMSE was most consistently used across studies [28, 35, 38, 40, 41, 78, 88, 90, 91, 99–103, 106–108, 110, 115, 116, 118] and was the only measure with sufficient data to investigate the association with: all social measures, measures of social activity, measures of social networks, and measures that combined social activity and networks. Heterogeneity was considerably reduced for each group of social measures when the MMSE was the only cognitive measure included in the sub-analyses (Table 4).

Table 4

Random effects sub-analyses for aspects of social isolation and the Mini-Mental State Examination (MMSE)

nkr95% CIpHeterogeneity
QQ pI2
  All social measures36,587180.0380.025, 0.050<0.00120.910.23018.71
  Social activity17,695120.0420.023, 0.062<0.00115.630.15629.60
  Social network16,80170.0310.015, 0.048<0.0016.350.3855.57
  Combination of social activity and social networks8,69530.0360.012, 0.0610.0032.540.28221.11

Methodological quality and publication bias

The results of the methodological quality assessment are reported in Table 1. Scores on the quality checklist ranged from 28 to 41 with a mean score of 38.11. Most articles did not use a standardized measure of social isolation and did not consider or compare the characteristics of participants lost to follow-up. There were no articles judged to be of poor methodological quality.

Funnel plots suggest that the results may be slightly overestimated due to publication bias: Egger’s test: b = 1.52, 95% CI: 0.746, 2.285, p < 0.001 (see Supplementary Material 4 for funnel plots).


The findings from this systematic review and meta-analysis of longitudinal cohort studies suggest that aspects of social isolation, including low levels of social activity and poor social networks, are significantly associated with poor cognitive function in later life. There was little difference in the effect sizes of reported associations when measures of social isolation were divided into social activity, social networks, and a combination of these two concepts, despite heterogeneous tests of global cognition, memory, and executive function being used. Effect sizes were also similar for men and women, and for number of years follow-up. The effect sizes indicate that having a large social network and engaging in social activity makes a small but statistically significant contribution to preventing poor cognitive function in later life. The size of effect is consistent with a previous review assessing the relationship between poor structural aspects of social relationships and cognitive decline [25]. The small effect size is unsurprising given the range of factors that contribute to maintaining healthy cognitive function [119, 120].

The moderate to high heterogeneity observed in the meta-analysis can be explained by several factors. First, three articles [86, 89, 92] reported effect sizes that were considerably higher than those reported by other included articles. Removing these studies from the meta-analysis reduced heterogeneity considerably and slightly reduced effect sizes. Second, sub-analyses were conducted on articles that assessed cognitive function using the MMSE, hence reducing the variance in assessments of cognitive function. This also considerably reduced heterogeneity and while effect sizes were reduced they remained statistically significant suggesting that global cognition as measured by the MMSE contributes to social activity and social networks.

A wide range of indicators to assess social networks (e.g, number of contacts, frequency of interaction, marital status, living arrangement) and social activity (e.g, attending social groups, visiting family, friends, and neighbors, engaging in voluntary or paid work, participation in cultural or leisure activities) was employed across articles, which may account for the remaining observed heterogeneity [25, 55]. Indeed, further sub-analyses suggested that the heterogeneity may partly be explained by including a range of indicators within measures of social activity and social networks. Heterogeneity was considerably lower for indicators that were specific in nature, such as voluntary or paid work, a count of the number of people within the social network, or social and community activities, which specifically considers social groups and community meetings where the primary outcome is social.

Conversely, heterogeneity was high for cultural and leisure activities, which reflects the diversity of activities that may be included within this indicator and highlights an important methodological issue. Many measures of social activity include questions regarding leisure and cultural activities [79, 81, 86]. These activities are not necessarily social in nature; for example, watching a film or engaging in hobbies may have less social input than visiting friends and family or attending a party. Many cultural and leisure activities present additional demands, for example, playing a game may be both cognitively and socially demanding, and engaging in group sport may be physically, cognitively, and socially demanding [28]. Individual differences may also influence the extent to which an activity is socially demanding [121]. For example, one person may join a bowling club to engage in physical activity, whereas another may enjoy the social aspect of group sports, and a third may gain more cognitive stimulation from thinking strategically about the game. This variation is reflected in the high heterogeneity reported for the specific indicator of leisure and cultural activities and highlights the complexity of assessing social concepts independently from other lifestyle factors and determining the extent of social demand across activities [28, 121]. Heterogeneity was also high for frequency of visits from or to, family, friends, and neighbors. This may be accounted for to some extent by differences in response scales employed across studies, for example, some studies ask about the number of visits received or made within a month [51, 92] while others consider frequency of visits ranging from daily, to yearly/less than yearly [86, 103] and others are more specific and require participants to give the number of hours spent visiting others or being visited [82]. Other studies categorize participants as receiving a high or low number of visits [50] and others are less specific with response categories ranging from never, sometimes, often [106]. The variation in methodological approaches to categorizing ‘frequency’ of visits may account for this heterogeneity.

Few studies reported findings for indicators of social activity or social networks separately and many indicators were included as a range of combinations in measures across studies, which again may account for the heterogeneity observed. Future research should aim to achieve consistency in measures of social concepts and report findings for specific indicators separately. This would enable conclusions regarding the nature of the association between specific aspects of social isolation and cognitive function to be established and inform future cohort or intervention studies [25, 55].

Few randomized controlled trials have investigated the effect of interventions to enhance social connections and cognitive function in later life [54, 122]. In a community-dwelling sample of 250 participants, an intervention to enhance social interaction improved cognitive function and resulted in significant increases in brain volume compared to a control group after 40 weeks [123]. Likewise, increased social activity in 235 lonely people enhanced cognitive function compared to a control group after 12 months [124]. While the effect size for this intervention was moderate the intervention was administered to people who were lonely and so may not be as effective for people who are socially isolated. In addition, a six-week intervention to increase social engagement facilitated by internet video communication was found to improve language based executive functions and psychomotor speed in cognitively healthy older people [125]. This suggests that communication facilitated by the internet may be a cost-effective home-based intervention to enhance social contact and improve cognitive function. Another study reported no beneficial effect of a pilot intervention to enhance social connections on cognitive function [126]. Nonetheless, only five participants were assigned to the social intervention in this study, therefore findings should be treated with caution. Although these studies provide some evidence that interventions to enhance social connections may support the maintenance of healthy cognitive function, both Mortimer et al. [123] and Park et al. [126] report that interventions of physical activity and cognitive activity were more beneficial for cognitive function than interventions to enhance social connections. This evidence, together with the small effect size reported in the meta-analysis may suggest that interventions targeting social isolation alone may be insufficient to reduce poor cognitive function in later life [127].

It is not surprising that the reported association between social isolation and cognitive function is small. There are multiple factors that could impact on trajectories of cognitive decline, including other modifiable lifestyle factors, such as physical exercise, education, occupational complexity, and cognitive activity [119, 120]. It is likely that a range of lifestyle factors, such as cognitive, social, and physical activity, contribute to the maintenance of healthy cognitive function [24, 49]. Cognitive reserve theory suggests that a combination of lifestyle factors across the lifespan contributes to enhancing cognitive reserve and hence maintaining healthy cognitive function [16]. Therefore, diverse environments and activities that increase cognitive stimulation through supporting a range of protective lifestyle factors may be most suitable to build cognitive reserve [54]. The lifestyle factors underpinning cognitive reserve are potentially amenable to change and hence may provide a basis for preventative intervention [21, 22]. This is supported by findings from a recent randomized controlled trial that suggests multi-domain interventions may be most appropriate for the maintenance of cognitive function [127]. Given the small effect sizes reported in the meta-analysis, an intervention to reduce social isolation may be most effective when implemented within a wider intervention that combines a range of lifestyle factors to enhance cognitive reserve [54, 127, 128].

Consistent with the present review, it has been found that poorer social relationships increase the risk of dementia [24, 54, 56, 129, 130]. Individual differences are observed in the expression of healthy cognitive aging and cognitive decline and progression to dementia [6–8]. In line with cognitive reserve theory, differences in trajectories may partly be explained by lifestyle factors [1, 16, 20]. The present review identifies social isolation, as determined by low engagement in social activity and smaller social networks, as a risk factor for poor cognitive function in later life. Future work investigating how integrating interventions to enhance social activity and social networks within multi-domain trials to prevent or delay poor cognitive function and hence progression to dementia is paramount [131]. This is particularly important given that an average delay of two years in the onset of dementia could reduce the worldwide prevalence by 22.8 million cases by 2050 [132].

Among the key strengths of this review, the comprehensive search included several concepts that are associated with social isolation. This enabled us to compare associations between different aspects of social isolation and cognition, including social activity and social networks both overall and separately. We consider the effects that different aspects of social isolation may have on global cognitive function and the specific cognitive domains of memory and executive function [133]. Although fewer studies assessed memory and executive function we found evidence that social isolation is associated with these specific cognitive domains. In addition, we excluded articles reporting findings from cross-sectional data to reduce the risk of reverse causality and enhance the reliability of findings in terms of causality [25, 46]. Only one previous review has used meta-analytic techniques to consider how aspects of social relationships may be associated with cognitive function [25]. We extend this review by considering aspects of social isolation and the association with cognitive function, as well as investigating gender differences in longitudinal studies. Considering gender differences is particularly important given that women may be more likely to engage in frequent social activity and are more likely to maintain close relationships and wider social networks than men [50, 97, 134–136]. Although we report a small association, this still reflects the benefits of social integration on cognitive function in later life for both men and women and is consistent with the findings of Kuiper et al. [25].

Some limitations of the review need to be addressed. First, there was considerable between-article heterogeneity. Additional analysis suggests that this may partly be accounted for by the differences in methodological approaches and range of indicators used to assess social concepts and cognitive function [25] and that other lifestyle factors may contribute to the maintenance of cognitive health [119, 120]; however, this limits our ability to draw definite conclusions regarding the nature of the association. There was evidence of a possible publication bias therefore the observed effect size may be slightly inflated. Studies with a larger sample size and that report a significant association between social relationships and cognitive function are more likely to be reported [137–139] which may account for the publication bias found in the meta-analysis. Including grey literature may have reduced this bias; however, grey literature tends to include studies with small samples and a number of large studies were included in the review that reported statistically non-significant findings. There are large differences in the number of years follow-up across articles which makes it difficult to compare findings. However, findings suggest that there were similar effect sizes irrespective of follow-up duration. An additional limitation applicable to most later life social isolation research is that although socially isolated older people are not uncommon, this group is particularly difficult to engage in research [55]. Therefore, people who are more extremely isolated may be underrepresented in studies that assess the association between social isolation and cognitive function and hence the effect size may be larger than that which we report. Finally, methodological quality was assessed by one reviewer, which may have influenced the methodological quality ratings. However, the ratings were based on standardized criteria and none of the studies were judged to be of poor quality.

We have demonstrated that in later life larger social networks and engagement in social activity are associated with better cognitive function. The reported association was small, which may be attributed to the methodological issues associated with assessing social concepts and the fact that social connections is only one of many factors that influence cognitive function over time. Future studies would benefit from using standardized measures to assess specific social concepts independently. In addition, more randomized controlled trials that assess the effectiveness of interventions to enhance social connections in later life should be conducted to determine whether this may improve cognitive function. This may further help to clarify the nature of the association between social connections and cognitive function in later life.


We are grateful to the Alzheimer’s Society for funding a PhD scholarship for Isobel Evans to complete this work through the following grant: Transdisciplinary training for dementia research in CFAS (The Alzheimer’s Society CFAS Doctoral Training Centre). 2015–2018. AS-DTC-2014-027.

Authors’ disclosures available online (


[1] The supplementary material is available in the electronic version of this article:



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