Parietal Involvement in the Semantic Variant of Primary Progressive Aphasia with Alzheimer’s Disease Cerebrospinal Fluid Profile

Article type: Research Article

Authors: Bera, Géraldine^{a; b; 1} | Migliaccio, Raffaella^{b; c; 1; *} | Michelin, Thibaut^a | Lamari, Foudil^d | Ferrieux, Sophie^c | Nogues, Marie^c | Bertin, Hugo^e | Habert, Marie Odile^{a; e; f} | Dubois, Bruno^{b; c} | Teichmann, Marc^{b; c} | Kas, Aurélie^{a; e; f}

Affiliations: [a] Service de Médecine Nucléaire, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, AP-HP, Paris CEDEX 13, France | [b] INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, and Université Pierre et Marie Curie-Paris 6, UMR S 1127, Institut du Cerveau et de la Moelle épinière (ICM), FrontLab, Paris CEDEX 13, France | [c] Département de Neurologie, Institut de la mémoire et de la maladie d’Alzheimer, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, AP-HP, Paris CEDEX 13, France | [d] Laboratoire de Biochimie, AP-HP, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, Paris CEDEX 13, France | [e] CATI, http://www.cati-neuroimaging.com | [f] Laboratoire d’Imagerie Biomédicale, INSERM U1146, Sorbonne Universités et Université Pierre et Marie Curie-Paris 6, Paris, France

Correspondence: [*] Correspondence to: Raffaella Migliaccio, Institut du cerveau et de la Moelle Epinière (ICM), FrontLAB, Inserm Unit 1127, 47-83 Bd de l’hôpital, 75651, Paris CEDEX 13, France. Tel.: +33 1 57 27 41 46; E-mail: [email protected] or E-mail: [email protected].

Note: [1] These authors equally contribute to this work.

Abstract: Semantic variant of primary progressive aphasia (svPPA) is typically associated with non-Alzheimer’s disease (AD) pathology. However, some anatomopathological studies have found AD lesions in those patients. We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant.

Keywords: Alzheimer’s disease, atypical AD, cerebrospinal fluid examination, parietal lobe, semantic variant of primary progressive aphasia, single photon emission computed tomography

DOI: 10.3233/JAD-180087

Journal: Journal of Alzheimer's Disease, vol. 66, no. 1, pp. 271-280, 2018