Personality Modulates the Efficacy of Art Intervention on Chronic Pain in a Population of Patients with Alzheimer’s Disease

Article type: Research Article

Authors: Rouch, Isabelle^{a; b; c; *} | Pongan, Elodie^{a; b; c} | Leveque, Yohana^d | Tillmann, Barbara^d | Trombert, Béatrice^e | Getenet, Jean Claude^a | Auguste, Nicolas^f | Krolak-Salmon, Pierre^{b; c; g} | the LACMé group¹ | Laurent, Bernard^{a; h} | Dorey, Jean-Michel^{g; i}

Affiliations: [a] Memory Clinical and Research Center of Saint Etienne (CMRR) Neurology Unit, University Hospital of Saint Etienne, Saint Etienne, France | [b] Memory Clinical and Research Center of Lyon (CMRR), Hospital of Charpennes, University Hospital of Lyon, France | [c] Institute of Aging I-Vie, University Hospital of Lyon, France | [d] INSERM, U1028, CNRS, UMR5292, University Lyon 1, Lyon Neuroscience Research Center, Psychoacoustic and Auditory Cognition team, Lyon, France | [e] Public Health and Medical Information Unit, University Hospital of Saint-Etienne, Saint Etienne, France | [f] Memory Clinical and Research Center of Saint Etienne (CMRR) Geriatrics Unit, University Hospital of Saint Etienne, Saint Etienne, France | [g] Brain Dynamics and Cognition, Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Lyon, France | [h] INSERM, U1028, CNRS, UMR5292, Neuropain team, Lyon Neuroscience Research Center, Lyon, France | [i] Department of Psychiatry, Hospital Le Vinatier, Bron, France

Correspondence: [*] Correspondence to: Isabelle Rouch, Memory Clinical and Research Center of Saint Etienne (CMRR), Neurology Unit, Hospital of Saint Etienne, Avenue Albert Raimond, 42055 Saint Etienne, France. Tel.: +33 4 77 12 73 98; Fax +33 4 77 12 72 79; E-mail: [email protected].

Note: [1] LACMé Group: Nicolas Auguste, Romain Bachelet, Laurence Brunon, Jenny Dayot, Jean-Michel Dorey, Hanane El Haouari, Marion Fatisson, Marion Ferrer, Charlotte Gaillat, Claire Gentil, Jean Claude Getenet, Karine Goldet, Pierre Krolak-Salmon, Bernard Laurent, Marie Leroyer, Yohana Leveque, Agnès Michon, Angélique Mortreux, Malou Navez, Anca Neagu, Catherine Perrot, Elodie Pongan, Isabelle Rouch, Mathilde Solimeo, Barbara Tillmann, Anaïs Touzet du Vigier, Elodie Vulliez.

Abstract: Background:Alzheimer’s disease (AD) mainly occurs in elderly individuals. Comorbidities and chronic pain are frequent in this population. Previous studies revealed that personality modulates both chronic pain (CP) andADoccurrence and evolution. Moreover, as pain treatments can induce side-effects, non-drugs treatments, such as art interventions, are interesting alternative therapies for decreasing CP in these patients. Objective:Our aim was to assess the potential role of personality traits on art intervention efficacy for reducing CP in a population of patients with mild AD. Methods:Design: multicenter randomized controlled trial. Fifty mild AD patients underwent a 12-week art intervention including singing and painting groups. Personality was assessed with the Big Five Inventory before the sessions. CP was measured with Numeric Rating Scale (NRS) [Usual pain (NRS-U) and most Intense pain (NRS-I)], Simple Visual Scale [Usual pain (SVS-U) and most Intense pain (SVS-I)] and Brief Pain Inventory (BPI) before and after the sessions. The influence of personality traits on CP evolution before and after art intervention was assessed with multiple linear regression models. Results:A positive association was observed between neuroticism and the evolution of three CP measures including NRS-U (B = 0.34, p = 0.01), SVS-U (B = 0.20, p = 0.04), and BPI-U (B = 0.46, p = 0.02) evolution. No significant relationship was observed between neuroticism and NRS-I, SVS-I and BPI-R evolution. Conclusions:Our findings suggest that neuroticism can decrease the efficacy of group art intervention on pain in patients with mild AD. Individual therapies could be more appropriate for these patients. These results emphasize the interest of taking into account patients’ personality before proposing them to participate to a group therapy.

Keywords: Alzheimer’s disease, music, pain, personality

DOI: 10.3233/JAD-170990

Journal: Journal of Alzheimer's Disease, vol. 63, no. 2, pp. 617-624, 2018