Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer’s and Lewy Body Diseases

Article type: Research Article

Authors: Babiloni, Claudio^{a; b; *} | Del Percio, Claudio^c | Lizio, Roberta^{a; b} | Noce, Giuseppe^c | Lopez, Susanna^a | Soricelli, Andrea^{c; d} | Ferri, Raffaele^e | Pascarelli, Maria Teresa^e | Catania, Valentina^e | Nobili, Flavio^f | Arnaldi, Dario^f | Famà, Francesco^f | Aarsland, Dag^g | Orzi, Francesco^h | Buttinelli, Carla^h | Giubilei, Franco^h | Onofrj, Marcoⁱ | Stocchi, Fabrizio^b | Vacca, Laura^b | Stirpe, Paola^b | Fuhr, Peter^j | Gschwandtner, Ute^j | Ransmayr, Gerhard^k | Garn, Heinrich^l | Fraioli, Lucia^m | Pievani, Michelaⁿ | Frisoni, Giovanni B.^{n; o} | D’Antonio, Fabrizia^p | De Lena, Carlo^p | Güntekin, Bahar^q | Hanoğlu, Lutfu^r | Başar, Erol^s | Yener, Görsev^s | Emek-Savaş, Derya Durusu^t | Triggiani, Antonio Ivano^u | Franciotti, Raffaellaⁱ | Taylor, John Paul^v | De Pandis, Maria Francesca^m | Bonanni, Lauraⁱ

Affiliations: [a] Department of Physiology and Pharmacology “Vittorio Erspamer”, University of Rome “La Sapienza”, Rome, Italy | [b] Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy | [c] Department of Integrated Imaging, IRCCS SDN, Naples, Italy | [d] Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy | [e] Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy | [f] Department of Neuroscience (DiNOGMI), Clinical Neurology, University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy | [g] Department of Old Age Psychiatry, King’s College University, London, UK | [h] Department of Neuroscience, Mental Health and Sensory Organs, University of Rome “La Sapienza”, Rome, Italy | [i] Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d’Annunzio of Chieti-Pescara, Chieti, Italy | [j] Universitätsspital Basel, Abteilung Neurophysiologie, Basel, Switzerland | [k] Department of Neurology 2, Med Campus III, Kepler University Hospital, Medical Faculty of the Johannes Kepler University, Linz, Austria | [l] AIT Austrian Institute of Technology GmbH, Vienna, Austria | [m] Hospital San Raffaele of Cassino, Italy | [n] Laboratory of Alzheimer’s Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy | [o] Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland | [p] Department of Neurology and Psychiatry, Sapienza, University of Rome, Italy | [q] Department of Biophysics, Istanbul Medipol University, Istanbul, Turkey | [r] Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey | [s] IBG, Departments of Neurology and Neurosciences, Dokuz Eylül University, Izmir, Turkey | [t] Department of Psychology and Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey | [u] Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy | [v] Institute of Neuroscience, Newcastle University, Newcastle, UK

Correspondence: [*] Correspondence to: Prof. Claudio Babiloni, PhD, Department of Physiology and Pharmacology “V. Erspamer”, University of Rome “La Sapienza”, P. le A. Moro 5, 00185, Rome, Italy. Tel.: +39 0649910989; E-mail: [email protected].

Abstract: The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer’s disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC >0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers.

Keywords: Exact low resolution brain electromagnetic source tomography (eLORETA), mild cognitive impairment due to Alzheimer’s disease, mild cognitive impairment due to dementia with Lewy bodies, receiver operating characteristic curve, resting state electroencephalographic rhythms

DOI: 10.3233/JAD-170703

Journal: Journal of Alzheimer's Disease, vol. 62, no. 1, pp. 247-268, 2018