Affiliations: [a] Cellular and Molecular Neurobiology Area, Group of Neuroscience, School of Medicine, SIU, University of Antioquia UdeA, Medellín, Colombia
| [b] Department of Systems Engineering, University of Antioquia UdeA, Medellín, Colombia
| [c] Neurobank, Group of Neuroscience, SIU, University of Antioquia, Medellín, Colombia
Correspondence:
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Correspondence to: Gloria Patricia Cardona-Gómez, Universidad de Antioquia, Sede de Investigación Universitaria (SIU), Calle 62 No. 52 –59, Torre 1, Piso 4, Laboratorio 412, Medellín, Colombia. Tel.: +57 4 2196458; Fax: +57 4 2196444; E-mail: [email protected].
Abstract: Lipids are considered important factors in the pathogenesis of Alzheimer’s disease (AD). In this study, we realized a comparative analysis of the phospholipid profile and phospholipid composition of the temporal cortex from E280A-familiar AD (FAD), sporadic AD (SAD), and healthy human brains. Findings showed a significant decrease of lysophosphatidylcholine and phosphatidylethanolamine formed by low levels of polyunsaturated fatty acids (20 : 4, 22 : 6) in AD brains. However, phosphatidylethanolamine-ceramide and phosphoglycerol were significantly increased in SAD, conformed by high levels of (18 : 0/18 : 1) and (30/32/36 : 0/1/2), respectively. Together, the findings suggest a deficiency in lysophosphacholine and phosphatidylethanolamine, and alteration in the balance between poly- and unsaturated fatty acids in both types of AD, and a differential pattern of phospholipid profile and fatty acid composition between E280A FAD and SAD human brains.
