Affiliations: [a] Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy
| [b] Parkinson’s Disease Rehabilitation Centre, FERB ONLUS S.Isidoro Hospital, Trescore Balneario (BG), Italy
| [c] Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Section of Public Health and Human Sciences, University of Brescia, Brescia, Italy
Correspondence:
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Correspondence to: Luca Rozzini, Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy. Tel.: +39 0303849231; E-mail: [email protected].
Abstract: Several studies showed high serum copper levels in Alzheimer’s disease (AD). The present study applied a newly developed method to detect serum copper free from proteins (free-Cu). Forty-four patients affected by dementia due to AD, thirty-six patients affected by mild cognitive impairment (MCI) due to AD, and twenty-eight healthy controls underwent clinical, cognitive, and MRI assessment. The new method showed higher free-Cu concentrations in MCI and dementia due to AD compared to controls (p < 0.0001). No correlation between copper levels, cognitive or MRI measures were found.
