Affiliations: [a] Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, P.R. China | [b] Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, P.R. China | [c] Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, P.R. China | [d] Key Neurodegenerative Laboratory of the Ministry of Education of the People’s Republic of China, Beijing, P.R. China | [e] National Clinical Research Center for Geriatric Disorders of the People’s Republic of China, Beijing, P.R. China | [f] Beijing Sihuan Pharmaceutical Co., Ltd. Beijing, P.R. China
Correspondence:
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Correspondence to: Professor Jianping Jia, Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, P.R. China. Tel.: +86 10 83198730; Fax: +86 1083171070; E-mail [email protected].
Note: [1] These authors contribute equally to this work.
Abstract: Background:Delayed Matching-to-Sample Task 48 (DMS48), a brief tool measuring visual recognition memory, is valid to identify the early stage of Alzheimer’s disease (AD) in Caucasians. However, little data is available in Chinese. Objective:To develop norms and optimal cutoff points for the DMS48 in Chinese elders. Methods:A cross-sectional study was conducted in seven memory clinics from five cities across China. DMS48 was applied to 369 Chinese aged 50 or older (138 cognitively normal [CN], 112 mild cognitive impairment due to AD (MCI-A), and 119 mild AD dementia). The demographic factors which influence DMS48 scores were investigated and the norms were established considering those factors. Receiver operating characteristic (ROC) analysis was used to determine the optimal cutoff points. Results:Age was shown to influence DMS48 scores (r = –0.36, p < 0.05), and we presented the age-stratified normative data for the DMS48. The optimal cutoff point is 42/43 for identifying cognitive impairment (MCI-A and AD dementia) against CN (sensitivity 97.80% and specificity 89.13%) and MCI-A against CN (sensitivity 86.60% and specificity 94.20%). A cutoff of 39/40 obtained good sensitivity (100.00%) and specificity (94.90%) in discriminating AD dementia from CN. The age-stratified optimal cutoff points for identifying MCI-A were 43/44 for individuals aged 50 to 59 years old, 42/43 for 60 to 69 years old, 41/42 for 70 to 79 years old, and 40/41 for 80 or older, respectively (sensitivity 84.80% and specificity 95.70%). Conclusion:This study proved that DMS48 is of good validation in screening MCI-A in elderly Chinese.
