Affiliations: [a] Neurology Unit, San Gerardo Hospital, Monza, Italy
| [b] School of Medicine and Surgery and Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Italy
| [c] Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy
| [d] Neurology Unit, Manzoni Hospital, Lecco, Italy
| [e] Neurology Unit, Spedali Civili and University of Brescia, Italy
| [f] Unitá Operativa Alzheimer, IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy
Correspondence:
[*]
Correspondence to: Lucio Tremolizzo, MD, PhD, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy. Tel.: +39 02 6448 8128; Fax: +39 02 6448 8108; E-mail: [email protected].
Abstract: Alcohol, coffee, and tobacco consumption was assessed on 151 FTD outpatients and 151 matched controls in a multicenter retrospective case-control design. No association was found for smoking and coffee intake. The risk of FTD was decreased by alcohol consumption (adj. OR 0.30, 95% CI 0.14–0.63); risk reduction was significant in current alcohol consumers (adj. OR 0.22, 95% CI 0.10–0.51). The risk of FTD inversely correlated with the duration of exposure (adj. OR 0.88, 95% CI 0.81–0.95, for every 5 years of exposure increase). Retrospective information and the unknown amount of consumed alcohol are limits of the present work.
