Affiliations: [a] Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
| [b] Department of Medicine, Division of Neurology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan
| [c] Department of Pulmonary Medicine, Nitobe Memorial Nakano General Hospital, Tokyo, Japan
| [d] Department of Pathology, Tokyo Medical Dental University, Tokyo, Japan
| [e] Department of Pathology, Nitobe Memorial Nakano General Hospital, Tokyo, Japan
Correspondence:
[*]
Correspondence to: Naoki Kasahata, Department of Medicine, Division of Neurology, Tokyo Metropolitan Ohtsuka Hospital, 2-8-1 Minamiohtsuka, Toshima-ku, Tokyo 170-8476, Japan. Tel.: +81 3 3941 3211; Fax: +81 3 3941 9557; E-mail: [email protected].
Abstract: We encountered an 83-year-old man with 3-repeat dominant grain-like tau deposition. Tau-positive lesions exhibited apparent similarity to argyrophilic grains in terms of their distribution in the ambient gyrus, amygdala, and dorsomedial temporal tip and the characteristic comma-like morphology. The abundant oligodendroglial tau immunoreactivities were 3-repeat dominant. Tuft-shaped astrocytes showed partial 3-repeat tau immnoreactivities. These grain-like structures, as well as tuft-shaped astrocytes and oligodendroglia, exhibited predominant 3-repeat tau immunoreactivity, suggesting that grain-like structures and their characteristic distribution are mutually linked and not unique to 4-repeat tau deposition. pTDP immunoreactivity, extensive macrophage infiltration, and spongiosis were associated with these 3-repeat tau deposits.
Keywords: 3-repeat tau, ambient gyrus, amygdala, astrocytic tau immunoreactivity, grain, oligodendroglial tau immunoreactivity, TDP-43, temporal tip
