Affiliations: [a] Brain and Mind Centre, Sydney Medical School, University of Sydney, Sydney, Australia
| [b] FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK
| [c]
Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australia
| [d] Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London, London, UK
| [e] Norwich Medical School, University of East Anglia, Norwich, UK
Correspondence:
[*]
Correspondence to: Prof. Michael Hornberger, Norwich Medical School, University of East Anglia, Norwich, NR47UQ, UK. Tel.: +44 1603 597139; E-mail: [email protected].
Abstract: Background:Diagnosis of behavioral variant frontotemporal dementia (bvFTD) can be challenging, in particular when patients present with significant memory problems, which can increase the chance of a misdiagnosis of Alzheimer’s disease (AD). Growing evidence suggests spatial orientation is a reliable cognitive marker able to differentiate these two clinical syndromes. Objective:Assess the integrity of egocentric and allocentric heading orientation and memory in bvFTD and AD, and their clinical implications. Method:A cohort of 22 patients with dementia (11 bvFTD; 11 AD) and 14 healthy controls were assessed on the virtual supermarket task of spatial orientation and a battery of standardized neuropsychological measures of visual and verbal memory performance. Results:Judgements of egocentric and allocentric heading direction were differentially impaired in bvFTD and AD, with AD performing significantly worse on egocentric heading judgements than bvFTD. Both patient cohorts, however, showed similar degree of impaired allocentric spatial representation, and associated hippocampal pathology. Conclusions:The findings suggest egocentric heading judgements offer a more sensitive discriminant of bvFTD and AD than allocentric map-based measures of spatial memory.
