Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis

Article type: Short Communication

Authors: Renard, Dimitri^{a; *} | Gabelle, Audrey^{b; c} | Hirtz, Christophe^b | Demattei, Christophe^d | Thouvenot, Eric^{a; e} | Lehmann, Sylvain^b

Affiliations: [a] Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes Cedex 4, France | [b] Laboratoire de Biochimie-Protéomique Clinique – IRMB – CCBHM - Inserm U11183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier Cedex 5, France | [c] Centre Mémoire de Ressources et de Recherche Montpellier, Département de Neurologie, CHU Montpellier, Hôpital Gui de Chauliac – Université de Montpellier, Montpellier Cedex 5, France | [d] Department of biostatistics (BESPIM), Nîmes University Hospital, Nîmes cedex 9, France | [e] Institut de Génomique Fonctionnelle, UMR5203, Université Montpellier, Montpellier Cedex 5, France

Correspondence: [*] Correspondence to: Dimitri Renard, MD, Department of Neurology, CHU Nîmes, Hôpital Caremeau, 4, Rue du Pr Debré, 30029 Nîmes Cedex 4, France. Tel.: +33 466683261; Fax: +33 466684016; E-mail: [email protected].

Abstract: We evaluated cerebrospinal fluid amyloid-β 1-40 (Aβ40), amyloid-β 1–42 (Aβ42), total and phosphorylated-tau (t-tau and p-tau) in patients with symptomatic isolated cortical supratentorial superficial siderosis (SS), by prospectively recruiting ten patients with SS in the absence of pre-existing cognitive dysfunction, and comparing biomarkers with lobar hematoma cerebral amyloid angiopathy patients (LH-CAA, n = 13), Alzheimer’s disease patients (AD, n = 42), and controls (n = 16). Compared to controls, SS patients showed statistically significant higher t-tau (p = 0.019) and lower Aβ42 (p = 0.0084). Compared to other groups, SS showed statistically significant lower t-tau, p-tau, and Aβ40 compared to AD (p = 0.0063, p = 0.0004, and p = 0022, respectively), and higher p-tau compared to LH-CAA (p = 0.012).

Keywords: Amyloid-β, cerebral amyloid angiopathy, cerebrospinal fluid, tau, superficial siderosis

DOI: 10.3233/JAD-160400

Journal: Journal of Alzheimer's Disease, vol. 54, no. 4, pp. 1291-1295, 2016