Moving from the Dish to the Clinical Practice: A Decade of Lessons and Perspectives from the Pre-Clinical and Clinical Stem Cell Studies for Alzheimer’s Disease

Article type: Research Article

Authors: Salem, Haitham^{a; b} | Rocha, Natalia Pessoa^a | Colpo, Gabriela Delevati^a | Teixeira, Antonio Lucio^{a; *}

Affiliations: [a] Department of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA | [b] Regenerative Medicine Program, University of Lübeck, Schleswig-Holstein, Germany

Correspondence: [*] Correspondence to: Antonio Lucio Teixeira, MD, PhD, Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center, BBSB 3140, 1941 East Road, Houston, TX 77054, USA. Tel.: +1 713 486 2555; Fax: +1 713 486 2553; E-mails: [email protected]/ [email protected].

Abstract: To date, there is no definitive treatment for Alzheimer’s disease (AD). The realm of stem cells is very promising in regenerative medicine, particularly neurodegenerative disorders. Various types of stem cells have been used in multiple trials on AD models, trying to find an innovative management of this disease. In this systematic review, we trace the published preclinical and clinical data throughout the last decade, to show how much knowledge we gained so far in this field and the future perspectives of stem cells in AD treatment.

Keywords: Alzheimer’s disease, clinical trails, neurodegenerative diseases, preclinical trials, stem cells

DOI: 10.3233/JAD-160250

Journal: Journal of Alzheimer's Disease, vol. 53, no. 3, pp. 1209-1230, 2016