Lifetime History of Depression Predicts Increased Amyloid-β Accumulation in Patients with Mild Cognitive Impairment
[Journal of Alzheimer’s Disease 45(3), 2015, 907-919.DOI 10.3233/JAD-142931]
The ADNI reported AV-45 mean values on figure 2 (page 912) and table 2 (page 914) were raw AV-45 values, and should be changed to AV-45 SUVR values.
Therefore, the regional AV-45 SUVR values on Figure 2 and table 2 have changed in the corrected Figure 2 and Table 2 below.
Table II
Comparison of region-of-interest based AV-45 SUVR between aMCI patients with a lifetime history of major depression and aMCI patients without a lifetime history of major depression
| Regions of interest | aMCI-LMD (n = 39) | aMCI+LMD (n = 39) | F-value | p-value | ||
| SUVR | (SD) | SUVR | (SD) | |||
| mean | mean | |||||
| Frontal ∗ | 1.32 | 0.21 | 1.39 | 0.27 | 4.29 | 0.04 ∗ |
| Cingulate | 1.43 | 0.21 | 1.50 | 0.29 | 3.94 | 0.05 |
| Parietal | 1.33 | 0.21 | 1.39 | 0.25 | 3.41 | 0.07 |
| Temporal | 1.24 | 0.19 | 1.29 | 0.23 | 2.88 | 0.10 |
Abbreviations: aMCI = amnestic mild cognitive impairment; aMCI+LMD = aMCI with a lifetime history of major depression; aMCI-LMD = aMCI without any lifetime history of major depression; ANCOVA = analysis of covariance; AV-45 SUVR =18F-Florbetapir standardized uptake value ratio with a reference to cerebellar grey matter.
