Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Barry, Heather E.a | Cooper, Janine A.a | Ryan, Cristína; b | Passmore, A. Peterc; d | Robinson, A. Louisee | Molloy, Gerard J.f | Darcy, Carmel M.g | Buchanan, Hilaryh | Hughes, Carmel M.a; *
Affiliations: [a] School of Pharmacy, Queen’s University Belfast, Belfast, UK | [b] School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland | [c] Centre for Public Health, Queen’s University Belfast, Belfast, UK | [d] Belfast Health & Social Care Trust, Belfast, UK | [e] Institute for Ageing and Health, Newcastle University, Newcastle, UK | [f] School of Psychology, National University of Ireland, Galway, Ireland | [g] Western Health & Social Care Trust, Londonderry, UK | [h] Belfast, UK
Correspondence: [*] Correspondence to: Professor Carmel M. Hughes, Clinical and Practice Research Group, School of Pharmacy, Queen’s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK. Tel.: +44 28 9097 2147; Fax: +44 28 9024 7794; E-mail: [email protected].
Abstract: Background: Little is known about prescribing appropriateness for community-dwelling people with dementia (PWD). Objective: To estimate potentially inappropriate prescribing (PIP) prevalence among PWD in primary care in Northern Ireland, and to investigate associations between PIP, polypharmacy, age, and gender. Methods: A retrospective cross-sectional study was conducted, using data from the Enhanced Prescribing Database. Patients were eligible if a medicine indicated for dementia management was dispensed to them during 1 January 2013–31 December 2013. Polypharmacy was indicated by use of ≥4 repeat medications from different drug groups. A subset of the Screening Tool of Older Persons Potentially Inappropriate Prescriptions (STOPP) criteria, comprising 36 indicators, was applied to the dataset. Overall prevalence of PIP and the prevalence per each STOPP criterion was calculated as a proportion of all eligible persons in the dataset. Logistic regression was used to investigate associations between PIP, polypharmacy, age, and gender. Results: The study population comprised 6826 patients. Polypharmacy was observed in 81.5% (n = 5564) of patients. PIP prevalence during the study period was 64.4% (95% CI 63.2– 65.5; n = 4393). The most common instance of PIP was the use of anticholinergic/antimuscarinic medications (25.2%; 95% CI 24.2–26.2; n = 1718). In multivariable analyses, both polypharmacy and gender (being female) were associated with PIP, with odds ratios of 7.6 (95% CI 6.6–8.7) and 1.3 (95% CI 1.2–1.4), respectively. No association was observed between PIP and age, after adjustments for gender and polypharmacy. Conclusion: This study identified a high prevalence of PIP in community-dwelling PWD. Future interventions may need to focus on certain therapeutic categories and polypharmacy.
Keywords: Dementia, inappropriate prescribing, pharmacoepidemiology, polypharmacy, primary health care
DOI: 10.3233/JAD-151177
Journal: Journal of Alzheimer's Disease, vol. 52, no. 4, pp. 1503-1513, 2016
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]