Normal Amplitude of Electroretinography and Visual Evoked Potential Responses in AβPP/PS1 Mice

Article type: Short Communication

Authors: Leinonen, Henri^* | Lipponen, Arto¹ | Gurevicius, Kestutis | Tanila, Heikki

Affiliations: University of Eastern Finland, A.I. Virtanen Institute, Department of Neurobiology, Kuopio, Finland

Correspondence: [*] Correspondence to: Henri Leinonen, A.I. Virtanen Institute, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. Tel.: +358407183789; E-mail: [email protected].

Note: [1] Current affiliation: University of Jyväskylä, Department of Psychology, Jyväskylä, Finland.

Abstract: Alzheimer’s disease has been shown to affect vision in human patients and animal models. This may pose the risk of bias in behavior studies and therefore requires comprehensive investigation. We recorded electroretinography (ERG) under isoflurane anesthesia and visual evoked potentials (VEP) in awake amyloid expressing AβPPswe/PS1dE9 (AβPP/PS1) and wild-type littermate mice at a symptomatic age. The VEPs in response to patterned stimuli were normal in AβPP/PS1 mice. They also showed normal ERG amplitude but slightly shortened ERG latency in dark-adapted conditions. Our results indicate subtle changes in visual processing in aged male AβPP/PS1 mice specifically at a retinal level.

Keywords: Alzheimer disease, amyloid-beta, animal models, electroretinography, vision, visual evoked potentials

DOI: 10.3233/JAD-150798

Journal: Journal of Alzheimer's Disease, vol. 51, no. 1, pp. 21-26, 2016