Affiliations: Centre de Psychiatrie et de Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Correspondence:
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Correspondence to: Dr Patrick Dutar, Centre de Psychiatrie et Neurosciences, UMR894 Inserm, 2ter rue d’Alésia, 75014 Paris, France. Tel.: +33 1 40 78 86 04; Fax: +33 1 45 80 72 93; [email protected]
Abstract: This study shows a decrease in soluble amyloid-β protein precursor-α (sAβPPα) levels, but no change in sAβPPβ, in the rat hippocampus during healthy aging, associated with the weaker expression of N-methyl-D-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) in the CA1 area of hippocampal slices. Exogenous application of recombinant sAβPPα increases NMDAR activation in aged animals and could rescue the age-related LTP deficits described. In contrast, it does not affect basal synaptic transmission or glutamate release. These results indicate that improving synaptic sAβPPα availability at synapses helps in reducing the functional NMDAR-related deregulation of hippocampal networks linked to aging.
