Interleukin-10 Production in Response to Amyloid-β Differs between Slow and Fast Decliners in Patients with Alzheimer’s Disease

Article type: Short Communication

Authors: Asselineau, Delphine^{a; b; c} | Benlhassan, Khadija^a | Arosio, Beatrice^{d; e; *} | Mari, Daniela^{d; e} | Ferri, Evelyn^d | Casati, Martina^d | Gussago, Cristina^d | Tedone, Enzo^d | Annoni, Giorgio^f | Mazzola, Paolo^f | Piette, Francois^g | Belmin, Joel^g | Pariel, Sylvie^g | Bornand, Anne^g | Beaudeux, Jean-Louis^{h; i} | Doulazmi, Mohamed^{b; c; g} | Mariani, Jean^{b; c; g} | Bray, Dorothy H.^a

Affiliations: [a] ImmunoClin Ltd, London, UK | [b] UPMC University Paris 06, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France | [c] CNRS, UMR 8256 Biological Adaptation and Ageing (B2A) Team Brain Development, Repair and Aging (BDRA), Paris, France | [d] Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Milan, Italy | [e] Geriatric Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy | [f] Geriatric Clinic, Department of Health Science, Milan Center for Neuroscience, University Study of Milano-Bicocca, Milan, Italy | [g] AP-HP, DHU FAST GH Pitie-Salpêtrière-Charles Foix, Paris, France | [h] UMR-S 1139 “Pathophysiology and pharmacotoxicology of human placenta”, Faculty of Pharmacy, Paris Descartes, Paris, France | [i] Department of Medical Biochemistry, Necker Hospital, AP-HP, Paris, France

Correspondence: [*] Correspondence to: Beatrice Arosio, PhD, Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy. Tel.: +39 02 55035405; Fax: +39 02 50320735; [email protected]

Abstract: We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer’s disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position -592, -819, -1082), IL-6 (-174), transforming growth factor-β1 (TGF-β1) (-10, -25), interferon-γ (IFN-γ) (-874), and tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. IL-10 production after Aβ stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-γ low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.

Keywords: Alzheimer’s disease, disease progression, IFN-γ, interleukin-6, interleukin-10, peripheral blood mononuclear cells, single nucleotide polymorphisms

DOI: 10.3233/JAD-142832

Journal: Journal of Alzheimer's Disease, vol. 46, no. 4, pp. 837-842, 2015