You are viewing a javascript disabled version of the site. Please enable Javascript for this site to function properly.
Go to headerGo to navigationGo to searchGo to contentsGo to footer
In content section. Select this link to jump to navigation

NT-proBNP and the Risk of Dementia: A Prospective Cohort Study with 14 Years of Follow-Up



Memory disorders and Alzheimer's disease (AD) share the same risk factors with cardiovascular diseases.


We tested whether elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels would predict any incident dementia or AD.


The association between NT-proBNP and the risk of dementia was evaluated in a total of 7,158 subjects without previous memory disorders in a prospective study with a median follow-up of 13.8 years.


A total of 220 new dementia cases occurred, of which 149 were AD. Baseline logNT-proBNP levels were associated significantly with the risk of dementia in the entire study population (HR 1.32, 95%CI 1.17–1.56, p = 0.001) per 1SD difference, adjusted for multiple cardiovascular risk factors. Integrated discrimination improvement (IDI) and continuous net-reclassification improvement (continuous NRI) were improved in the study population over 40 years of age: continuous NRI was 17.5% (95%CI 4.4–30.6%, p = 0.009) and IDI was 0.005 (95%CI 0.001–0.010, p = 0.021). Regarding AD, the HR for 1SD logNT-proBNP change was 1.23 (95%CI 1.01–1.49, p = 0.040) in the entire study population, but no IDI or continuous NRI improvement was seen.


NT-proBNP is also an independent risk marker for dementia, and patient discrimination regarding dementia risk could be improved by using it.