Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Wang, Juna | Tan, Lana; b; * | Wang, Hui-Fub | Tan, Chen-Chena | Meng, Xiang-Feia | Wang, Chonga | Tang, Shao-Wenc | Yu, Jin-Taia; b; d; *
Affiliations: [a] Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China | [b] Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China | [c] Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China | [d] Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
Correspondence: [*] Correspondence to: Dr. Lan Tan or Jin-Tai Yu, Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province 266071, China. E-mail: [email protected] (L. Tan); E-mail: [email protected] (J.T. Yu).
Abstract: Background:In the past 20 years, substantial evidence from laboratory and epidemiologic studies have suggested that anti-inflammatory medications could defer or prevent the occurrence of Alzheimer's disease (AD). However, several studies do not corroborate these findings. Objective:To evaluate the association of anti-inflammatory drug use on the incidence of AD. Methods:Pubmed, Embase, and Cochrane Library databases were searched up to March 2014. Studies evaluating the association between use of anti-inflammatory drugs and AD risk were included. Relative risks (RRs) with 95% confidence intervals (CIs) were meta-analyzed using random effects models and were grouped by anti-inflammatory type and duration of drug use. Results:In observational studies, use of non-steroidal anti-inflammatory drugs (NSAIDs) was significantly associated with a reduced risk of AD (RR, 0.72; 95%CI, 0.62–0.84) compared to no use of NSAIDs, especially in long term users (RR, 0.36; 95%CI, 0.17–0.74); the risks of AD were also lower in both aspirin (RR, 0.77; 95%CI, 0.63–0.95) and non-aspirin NSAID users (RR, 0.65; 95%CI, 0.47–0.88) compared with nonusers; whereas the use of corticosteroids showed no significant association (RR, 0.62; 95%CI, 0.26–1.46). In the single randomized controlled trial (RCT), NSAID use showed no significant effect on AD risk among dementia-free individuals (p > 0.05). Conclusion:Observational studies support the use of NSAIDs for prevention of AD, but RCT do not. Well-designed studies and innovative approaches are required to illuminate the exact relationship between NSAID use and AD risk. The appropriate dosage and duration of use to benefit and the safety are also needed to determine.
Keywords: Alzheimer's disease, anti-inflammatory drug, aspirin, meta-analysis, NSAIDs, prevention, systematic review
DOI: 10.3233/JAD-141506
Journal: Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 385-396, 2015
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]