Correspondence:
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Correspondence to: Euphrosyni Koutsouraki, MD, PhD, Assistant Professor of Neurology, Aristotle University, 1st Department of Neurology, AHEPA Hospital, Stilponos Kyriakidis 1, 54261 Thessaloniki, Greece. Tel.: +30 2310 994604; Fax: +30 2310 994711; E-mail: [email protected].
Abstract: We examined the sera of 103 demented patients of a mean age of 75 years and 60 age-matched healthy individuals, using ELISA, to investigate the levels of IgM antibodies against GM1, GD1b, and GQ1b gangliosides and their possible correlation with clinical parameters (age, severity, and type of dementia). All the individuals that demonstrated positive titers of anti-ganglioside antibodies were demented patients whereas normal controls showed borderline or negative values. Significant correlation was revealed between IgM anti-GM1 and both the age of the patients and the severity of dementia. Most of the patients with increased IgM anti-GD1b titers suffered from AD.
