Affiliations: Division of Molecular Psychiatry, Georg-August-University Göttingen, University Medicine Göttingen, Göttingen, Germany
Correspondence:
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Correspondence to: Oliver Wirths, Ph.D., Division of Molecular Psychiatry, Georg-August-University Göttingen, University Medicine Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany. Tel.: +49 551 10290; Fax: +49 551 10291; E-mail: [email protected].
Abstract: The triple-transgenic Alzheimer's disease (AD) mouse model, 3xTg-AD, played an important role in supporting the intraneuronal amyloid-β (Aβ) hypothesis in AD. However, recent evidence claims that the 3xTg-AD mice accumulate amyloid-β protein precursor (AβPP) instead of Aβ within neurons. In the present report, we re-investigated the 3xTg-AD mouse model and confirmed recent findings of age-dependent AβPP accumulations. In addition, intraneuronal Aβ was detected mainly in the neocortex using conformation-specific as well as antibodies directed against Aβ neo-epitopes. In contrast to previous work, however, only minor levels of intraneuronal Aβ were detected in the CA1 region of the hippocampus in aged 3xTg-AD mice.
