Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Olazarán, Javiera; * | Agüera-Ortiz, Luisb | Osorio, Ricardo S.a | León-Salas, Beatriza | Dobato, José Luisa | Cruz-Orduña, Isabela | González, Beléna | Valentí, Meritxella | Gil-Ruiz, Nuriaa | Frades, Belénc | Ramos-García, M.I.a | Martínez-Martín, Pabloc
Affiliations: [a] Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain | [b] CIBERSAM, Carlos III Institute of Health, Madrid, Spain | [c] CIBERNED, Carlos III Institute of Health, Madrid, Spain
Correspondence: [*] Correspondence to: Javier Olazarán, Unidad de Investigación Proyecto Alzheimer, Centro Alzheimer Fundación Reina Sofía – Fundación CIEN, Valderrebollo 5, Madrid 28031 Spain. Tel.: +00 34 913852200; Fax: +00 34 913852118; E-mail: [email protected].
Abstract: The Alzheimer Center Reina Sofía Foundation (ACRSF) was envisaged to address the complex and multi-disciplinary research and care needs posed by Alzheimer's disease (AD) and other neurodegenerative dementias. Patients may be admitted at ACRSF either as inpatients (i.e., nursing home) or outpatients (i.e., day-care center). The research program includes clinical, social, biochemical, genetic, and magnetic resonance investigations, as well as brain donation. We present the inception of the clinical research protocol for the ACRSF, the early results, and the amendments to the protocol. Foreseen as distinct populations, inpatient and outpatient results are presented separately. Data were collected from 180 patients (153 inpatients, 27 outpatients) (86% AD), with informed consent for participation in the research program of the ACRSF. Most patients (95%) had moderate to severe dementia. Nursing home patients were older, displayed marked gait dysfunction, and were significantly more dependent in the activities of daily living (ADL), compared to the day-care patients (p < 0.05). Some cognitive, ADL, and quality of life (QoL) scales were eliminated from the protocol due to floor effect or lack of specificity of contents for advanced dementia. New measurements were added for evaluation of cognition, apathy, agitation, depression, ADL, motor function, and QoL. The final assessment is expected to be sensitive to change in all the clinical aspects of advanced degenerative dementia, to promote multidisciplinary and, desirably, inter-center collaborative research and, eventually, to contribute to the improvement of treatment and care for these patients.
Keywords: Alzheimer's disease, clinical research protocol, geriatric assessment, inpatients, nursing homes, outpatients, primary senile degenerative dementia
DOI: 10.3233/JAD-2011-110875
Journal: Journal of Alzheimer's Disease, vol. 28, no. 1, pp. 211-222, 2012
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]