Affiliations: Klinik für Anästhesiologie, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr, München, Germany | [x] Neurospectroscopy and Neuroimaging Laboratory, National Brain Research Center, Manesar, Gurgaon, India | [y] Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
Correspondence:
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Correspondence to: Barbara Eckel, Klinik für Anästhesiologie, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675 München, Germany. Tel.: +49 (0)89 4140 4291; Fax: +49 (0)89 4140 4886; E-mail: [email protected].
Abstract: At present, more than 35 million people worldwide have Alzheimer's disease (AD). With increasing incidence and a growing number of aged patients undergoing surgery, the relevance of a possible interaction between anesthetics and AD is growing as well. Below, we review in vitro studies investigating the effects of anesthetics on the metabolism of amyloid precursor protein and its metabolite amyloid-β.
Keywords: Alzheimer's disease, amyloid, amyloid-β protein precursor, anesthetics, in vitro
