Plasma Carbonic Anhydrase II protein is Elevated in Alzheimer's Disease

Article type: Research Article

Authors: Jang, Bong Geom^{a; 1; 2} | Yun, Sang-Moon^{a; 1} | Ahn, Kyungsook^a | Song, Ju Hee^a | Jo, Sangmee A.^a | Kim, Young-Yul^{a; *} | Kim, Doh Kwan^b | Park, Moon Ho^c | Han, Changsu^d | Koh, Young Ho^a

Affiliations: [a] Division of Brain Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, Korea | [b] Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea | [c] Department of Neurology, Korea University Medical College, Ansan Hospital, Korea | [d] Department of Psychiatry, Korea University Medical College, Ansan Hospital, Korea

Correspondence: [*] Correspondence to: Young Ho Koh, Ph.D. Division of Brain Diseases, Center for Biomedical Sciences, National Institute of Health, 194 Tongillo, Eunpyeong-gu, Seoul 122-701, Korea. Tel.: +82 2 380 1527; Fax: +82 2 354 1057; E-mail: [email protected].

Note: [1] These authors contributed equally to this work.

Note: [2] Current address: Department of Physiology, College of Medicine, Hallym University, Chuncheon, Kangwon, 200-702, Korea.

Note: [] Handling Associate Editor: D. Allan Butterfield

Abstract: Carbonic anhydrase (CA) plays a critical role in pH regulation, long-term synaptic transformation, and is associated with mental retardation, Alzheimer's disease (AD), and Down syndrome. There is accumulating evidence that CAII is increased in AD brain. The present study focused on the determination of CAII protein level in blood plasma samples using immunoblot and ELISA methods. We compared plasma from 91 AD patients (average age 74.8 y), 83 persons with amnestic mild cognitive impairment (MCI) (average age 73.7 y), and 113 cognitively normal controls (average age 70.8 y). The plasma level of CAII was significantly increased in AD patients, as compared to control groups. CAII levels were higher in males than females. There was an age-dependent increase of CAII. These results provide further evidence that changes in CAII level may play a role in the pathogenesis of AD.

Keywords: Alzheimer's disease, carbonic anhydrase II, mild cognitive impairment, plasma

DOI: 10.3233/JAD-2010-100384

Journal: Journal of Alzheimer's Disease, vol. 21, no. 3, pp. 939-945, 2010