Bioavailable Testosterone Predicts a Lower Risk of Alzheimer's Disease in Older Men

Article type: Research Article

Authors: Chu, Leung-Wing^{a; d; g; h; *} | Tam, Sidney^{b; d} | Wong, Rachel L.C.^{c; d} | Yik, Ping-Yiu^a | Song, Youqiang^{e; g} | Cheung, Bernard M.Y.^{d; f} | Morley, John E.ⁱ | Lam, Karen S.L.^{c; d; g}

Affiliations: [a] Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong | [b] Division of Clinical Biochemistry, Queen Mary Hospital, The University of Hong Kong | [c] Division of Endocrinology and Metabolism, Department of Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong | [d] Research Centre of Heart, Brain, Hormone & Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong | [e] Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong | [f] Division of Clinical Pharmacology, Department of Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong | [g] Alzheimer's Disease Research Network, The University of Hong Kong | [h] Sau Po Centre on Ageing, Department of Medicine, The University of Hong Kong | [i] Division of Geriatric Medicine, Saint Louis University Medical School, St. Louis, USA

Correspondence: [*] Correspondence to: Dr. Leung-Wing Chu, MD (HK), MBBS (HK), FRCP (Edin), FRCP (Glas), Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong Kong SAR. Tel.: +852 2255 3315; Fax: +852 2974 1171; E-mail: [email protected].

Abstract: There is a paucity of data on the relationship between testosterone and Alzheimer's disease (AD) in older men. The objective of the present study was to investigate the effects of serum total testosterone (TT), bioavailable testosterone (BT), and sex hormone binding globulin (SHBG) levels on the subsequent risk of AD in non-demented Chinese older men. This was a one-year prospective cohort study. 153 ambulatory community-living non-demented Chinese older men, aged 55 years or over, were recruited and followed for one year. Morning serum TT, BT, and SHBG levels were measured at baseline. At one-year of follow-up, assessment for dementia and AD were performed. AD was diagnosed by the NINCDS-ADRDA criteria for probable AD. Overall, the mean age of the subjects was 72.7 (SD 6.9). 6.5% (n = 10) developed dementia (converters), all having AD. 93.5% (n = 143) did not develop dementia (non-converters). Logistic regression analysis for independent predictors of AD~showed that the baseline serum BT level, systolic blood pressure (SBP) and ApoE ε4 genotype were significant independent predictors, after adjustment for age, education, BMI, fasting plasma glucose, and serum HDL-C levels. The baseline serum BT level predicted a reduced risk of AD (adjusted relative risk (RR) 0.22, 95% CI: 0.07–0.69)). Baseline SBP and ApoE ε4 genotype but not SHBG were independent risk factors, with RRs of 1.04 and 5.04 respectively. In conclusion, the serum level of bioavailable testosterone in late life predicts a lower risk of future AD development in older men.

Keywords: Aging, Alzheimer's disease, Chinese, men, testosterone

DOI: 10.3233/JAD-2010-100027

Journal: Journal of Alzheimer's Disease, vol. 21, no. 4, pp. 1335-1345 , 2010