GOLPH2 Gene Markers are Not Associated with Alzheimer's Disease in a Sample of the Spanish Population

Article type: Short Communication

Authors: Antúnez, Carmen^{a; b} | Boada, Mercé^{c; d} | López-Arrieta, Jesús^e | Ramirez-Lorca, Reposo^f | Hernández, Isabel^c | Marín, Juan^a | Martínez-Lage, Pablo^c | González-Pérez, Antonio^f | Jorge Galan, José^f | Gayán, Javier^f | Real, Luis M.^f | Ruiz, Agustín^{f; *}

Affiliations: [a] Dementia Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain | [b] AlzheimUr Foundation, Murcia, Spain | [c] ACE Foundation, Catalan Institute of Applied Neurosciences, Spain | [d] Neurology Service, University General Hospital Vall d'Hebron, Barcelona, Spain | [e] Memory Unit, University Hospital La Paz-Cantoblanco, Madrid, Spain | [f] Department of Structural Genomics, NeoCodex, Sevilla, Spain

Correspondence: [*] Corresponding author: Dr. Agustín Ruiz, Department of Structural Genomics, Neocodex SL, Avda. Charles Darwin 6, Acceso A. Parque Científico y Tecnológico Isla de la Cartuja, 41092-Seville, Spain. E-mail: [email protected].

Abstract: GOLPH2 gene SNP variants Rs10868366 and Rs7019241 were reported to decrease the risk of Alzheimer's disease in a recent Whole Genome Association Study. We have investigated these genetic variants in 2470 individuals from Spain to conduct an independent replication study of the proposed SNP markers. We found no evidence of association between GOLPH2 markers and susceptibility to Alzheimer's disease in our series. We concluded that GOLPH2 gene does not contribute to risk of disease in this study sample.

Keywords: Alzheimer's disease, complex diseases, genetic susceptibility, Genome Wide Association Studies (GWAS), GOLPH2, human molecular genetics, neurodegeneration

DOI: 10.3233/JAD-2009-1200

Journal: Journal of Alzheimer's Disease, vol. 18, no. 4, pp. 751-754, 2009