Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Peterson, Dylan W.a | George, Roshni C.a | Scaramozzino, Francescaa | LaPointe, Nichole E.a | Anderson, Richard A.b | Graves, Donald J.a; | Lew, Johna; *;
Affiliations: [a] Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA | [b] Beltsville Human Nutrition Center, Beltsville, MD, USA
Correspondence: [*] Corresponding author: John Lew, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. Tel.: +1 805 893 5336; Fax: +1 805 893 2212; E-mail: [email protected].
Note: [1] These authors contributed equally.
Abstract: An aqueous extract of Ceylon cinnamon (C. zeylanicum) is found to inhibit tau aggregation and filament formation, hallmarks of Alzheimer's disease (AD). The extract can also promote complete disassembly of recombinant tau filaments and cause substantial alteration of the morphology of paired-helical filaments isolated from AD brain. Cinnamon extract (CE) was not deleterious to the normal cellular function of tau, namely the assembly of free tubulin into microtubules. An A-linked proanthocyanidin trimer molecule was purified from the extract and shown to contain a significant proportion of the inhibitory activity. Treatment with polyvinylpyrolidone effectively depleted all proanthocyanidins from the extract solution and removed the majority, but not all, of the inhibitory activity. The remainder inhibitory activity could be attributed to cinnamaldehyde. This work shows that compounds endogenous to cinnamon may be beneficial to AD themselves or may guide the discovery of other potential therapeutics if their mechanisms of action can be discerned.
Keywords: Aggregation, Alzheimer's disease, cinnamaldehyde, cinnamon extract, filaments, proanthocyanidin, tau
DOI: 10.3233/JAD-2009-1083
Journal: Journal of Alzheimer's Disease, vol. 17, no. 3, pp. 585-597, 2009
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]