Affiliations: [a] Department of Neurology, University of Turku, Turku, Finland | [b] Turku PET Centre, University of Turku, Turku, Finland | [c] Department of Psychology, Åbo Akademi University, Turku, Finland
Correspondence:
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Corresponding author: Juha O. Rinne, MD, PhD, Turku PET Centre, University of Turku, P.O.Box 52, 20521 Turku, Finland. Tel.: +358 2 313 1866, Fax: +358 2 2318191, E-mail: [email protected].
Abstract: Posterior cortical atrophy (PCA) is a rare form of degenerative dementia, which is characterized by progressive atrophy of occipital and parietal cortical areas. It usually manifests as increasing difficulties of visuoperceptive abilities. Later on, memory and other cognitive functions are involved. Various pathologies have been associated with clinical PCA presentation, but most of the patients with autopsy have had Alzheimer-type pathology. Thus, PCA has been considered to be a rare form of Alzheimer-type dementia with unusual pathological distribution. Here we describe a patient who had a typical clinical course for this syndrome and who showed a positive accumulation of amyloid-β in posterior areas studied with positron emission tomography.
Keywords: Alzheimer's disease, amyloid-β, PET imaging, posterior cortical atrophy
