Correlation between Platelet Amyloid Precursor Protein Isoform Ratio and Cognition in Alzheimer's Disease

Article type: Research Article

Authors: Liu, Hsiu-Chih^{a; d} | Wang, Hsiao-Chien^d | Ko, Shun-Yao^e | Wang, Pei-Ning^{a; d} | Chi, Chin-Wen^{b; e} | Hong, Chen-Jee^{c; f} | Lin, Ker-Neng^{d; g} | Liu, Tsung-Yun^{b; e; *}

Affiliations: [a] Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan | [b] Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan | [c] Department of Psychiatry, National Yang-Ming University School of Medicine, Taipei, Taiwan | [d] The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan | [e] Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan | [f] Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan | [g] Department of Psychology, Fu Jen Catholic University, Taipei, Taiwan

Correspondence: [*] Correspondence: Dr. Tsung-Yun Liu, Department of Medical Research and Education, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. Tel.: +886 2 28747848; Fax: +886 2 28751562; E-mail: [email protected]

Abstract: This study analyzed whether platelet amyloid β-protein precursor (AβPP) isoform ratio correlates with cognition or cognitive decline in patients with Alzheimer's disease (AD). Platelet AβPP isoform ratio was measured, and cognitive assessment was performed using the Mini-Mental State Examination (MMSE) in 66 AD patients at baseline (T0) and in 29 of these patients in a one-year follow-up (T1). There was a significant correlation between the AβPP isoform ratios and MMSE scores in the 66 AD patients at T0. The T1 subjects were divided into two groups: 12 “no decliners” (MMSE score, T1–T0 ⩾ 0) and 17 “decliners” (MMSE score, T1–T0 < 0). The decliners group showed a significantly greater reduction of AβPP isoform ratio from T0 to T1 than the no decliners group. However, the decline of the ratio did not correlate with the decline of MMSE score. These findings indicate that AβPP isoform ratio correlates with cognition, and reduction in this ratio may be a marker for cognitive decline in AD patients.

Keywords: Alzheimer's disease, platelet, amyloid β-protein precursor (AβPP), AβPP isoform ratio, and Mini-Mental State Examination (MMSE)

DOI: 10.3233/JAD-2007-11111

Journal: Journal of Alzheimer's Disease, vol. 11, no. 1, pp. 77-84, 2007