Solving the insoluble

Article type: Research Article

Authors: Perry, George

Affiliations: Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA. Tel.: +1 216 368 2488; Fax: +1 216 368 8964; E-mail: [email protected].

Abstract: Dissection of neurofibrillary tangles has been confounded by the insolubility of their fibers. While the majority of biochemical studies have considered τ filaments equivalent to neurofibrillary tangles, they forget that the former are soluble and the latter completely resistant to solvents. What, then, accounts for the insolubility of neurofibrillary tangles while τ filaments are soluble? Investigation of these distinctions played a critical role in our findings on proteolytic abnormalities and oxidative stress.

DOI: 10.3233/JAD-2006-9S333

Journal: Journal of Alzheimer's Disease, vol. 9, no. s3, pp. 301-304, 2006