Affiliations: [a] Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, Pisa, Italy | [b] Dipartimento di Chimica e Chimica Industriale Università di Pisa, Pisa, Italy | Institut für Biochemie und Molekularbiologie I, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany Tel.: +49 211 811 5358; Fax: +49 211 811 3029; E-mail: [email protected]
Correspondence:
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Corresponding author: Prof. Ettore Bergamini, Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, Via Roma 55, 56126 Pisa, Italy. Tel.: +39 50 2218584; Fax: +39 50 2218581; E-mail: [email protected].
Note: [**] Present address: NEST, Scuola Normale Superiore di Pisa, Pisa, Italy
Abstract: Dolichol is a polyprenol compound broadly distributed in membranes, biosynthetized by the general isoprenoid pathway from acetate via mevalonate and farnesyl pyrophosphate. Dolichol lays inside the membrane between the two leaflets of the lipid bilayer very close to the tail of phospholipid fatty acids. No definite catabolic pathways for this molecule have yet been identified. Evidence is produced that dolichol levels increase dramatically with increasing age; that anti-ageing caloric restriction retards this age-associated change; that dolichol may act as a radical scavenger of peroxidized lipids belonging to the cell membranes. In view of the polyunsaturated fatty acids (PUFA), dolichol and Vitamin E location and stechiometry, it is proposed that molecules might interact each-other to form a highly matched free-radical-transfer chain, whose malfunctioning might be involved in statin toxicity and neurodegenerative diseases.
Keywords: dolichol, vitamin E, PUFA, antioxidants in membrane, ageing
