Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Mendiondo, Marta S.a; * | Ashford, J. Wessonb; ** | Kryscio, Richard J.c | Schmitt, Frederick A.d
Affiliations: [a] School of Public Health, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA | [b] Department of Psychiatry, Sanders-Brown Center on Aging, University of Kentucky., Lexington, KY, USA | [c] Department of Statistics and School of Public Health, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA | [d] Departments of Neurology, Psychiatry, Psychology, and Behavioral Science, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
Correspondence: [*] Corresponding author. Marta S. Mendiondo, 207A Sanders-Brown Center on Aging, 800 South Limestone, University of Kentucky, Lexington, KY 40536, USA. Tel.: +1 859 257 1412 ext 274; Fax: +1 859 323 1772; E-mail: [email protected]
Note: [**] Alzheimer Center Stanford — Palo Alto Veterans Administration Hospital, Palo Alto, CA, USA.
Abstract: Context:With advances in the treatment of Alzheimer’s disease (AD), clinical focus has shifted to early patient identification. Memory recall tests and category fluency distinguish normal individuals from early AD patients. Objective:Develop a brief test for general practitioners to screen for AD. Design:Examination of items from the MMSE and category fluency. Setting and Participants:A Brief Alzheimer Screen (BAS) was developed from cognitive assessments on 406 normal subjects and 342 mild AD patients in the CERAD (Consortium to Establish a Registry for AD) dataset. The derived measure was then applied to a second validation sample. Main Outcome Measure:Logistic regression was used to derive a predictive equation, which was then applied to two validation samples to estimate sensitivity and specificity. Results:The resulting logistic model for discriminating between mild AD and controls included: recall of 3 words, number of animals named in 30 seconds, date, and spelling of WORLD backwards, (p < 0.001 for each) accounting for 77% of the variance. When applied to the validation samples, sensitivity and specificity were over 99% and 87%, respectively. Conclusions:These data support the use of the BAS as a potential screen of patients over 60 years of age.
DOI: 10.3233/JAD-2003-5506
Journal: Journal of Alzheimer's Disease, vol. 5, no. 5, pp. 391-398, 2003
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]