Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Bienias, Julia L.a; * | Beckett, Laurel A.c | Bennett, David A.b | Wilson, Robert S.b | Evans, Denis A.a
Affiliations: [a] Rush Institute for Healthy Aging, Rush University, Chicago, IL, USA | [b] Rush Alzheimer's Disease Center, Rush University, Chicago, IL, USA | [c] Department of Epidemiology and Preventive Medicine, University of California, Davis, USA
Correspondence: [*] Corresponding author. Dr. Julia L. Bienias, Rush Institute for Healthy Aging, 1645 W. Jackson Blvd., Suite 675, Chicago, IL 60612, (312) 942-3350, USA. E-mail: [email protected].
Abstract: The design of the Chicago Health and Aging Project (CHAP) is described. CHAP is a longitudinal population study of common chronic health problems of older persons, especially of risk factors for incident Alzheimer's disease, in a biracial neighborhood of the south side of Chicago. Special attention is given to three unusual design features of the study. One feature is that clinical evaluation for Alzheimer's disease is confined to a stratified random sample of all participants. This feature results in substantial cost savings and substantially less bias than screening approaches but has the disadvantages of adding analytic complexity and requiring the use of indirect means to identify a disease-free cohort for the development of incident Alzheimer's disease. The second unusual feature is efficiently combining in analyses the successive independent multiple samples that are drawn, one from each data collection cycle. The third unusual feature is entering successive age cohorts of community residents into the study as they attain 65 years of age. This has the advantages of enhancing direct investigation of the effect of age on the action of risk factors for Alzheimer's disease and direct examination of cohort effects. The interaction of these features is described, especially as they pertain to a study in which data are collected in successive waves. The results from these waves must be combined for effective analysis of the relation among risk factors and incident disease.
Keywords: aging, Alzheimer's disease, longitudinal study, community study, random sampling
DOI: 10.3233/JAD-2003-5501
Journal: Journal of Alzheimer's Disease, vol. 5, no. 5, pp. 349-355, 2003
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]