Affiliations: [a] Department for Psychiatry and Psychiatry, University of Erlangen-Nurenberg, Erlangen, Germany | [b] Clinic of Nuclear Medicine, University Hospital, University of Erlangen-Nurenberg, Erlangen, Germany
Correspondence:
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Correspondence to: Markus Weih, Universitätsklinikum Erlangen, Psychiatrische und Psychotherapeutische Klinik, Schwabachanlage 6, 91054 Erlangen, Germany. Tel.: +09131 85 34262; Fax: +09131 85 36002; E-mail: [email protected]; Website: www.psych.med.uni-erlangen.de.
Abstract: Nuclear medicine techniques were the first functional imaging techniques used to support the clinical diagnosis of Alzheimer's Disease (AD). Perfusion-SPECT allows registration of regional cerebral blood flow (rCBF) which is altered in a characteristic temporal-parietal pattern in AD. Numerous studies have shown the diagnostic value of reduced CBF and metabolic changes using perfusion-SPECT and FDG-PET in AD diagnosis as well as in differential diagnosis against frontotemporal dementia (FTD), dementia with Lewy-Bodies (DLB), and vascular cognitive disorders. This renders perfusion-SPECT an important piece of the puzzle (together with other diagnostic tests) by the clinician is often faced when making a final etiologic dementia diagnosis especially between AD and FTD. A similar diagnostic value can be expected when arterial spin labeling (ASL) MRI sequence is used, but the diagnostic value has yet to be confirmed in lager studies. Recently, more pathophysiology-based biomarkers in CSF and Amyloid-PET tracers have been developed that probably have a higher diagnostic accuracy than the more indirect rCBF changes seen in perfusion-SPECT. In the current review, we describe recent advances in AD biomarkers as well as improvements in the SPECT technique.
