DTI Analyses and Clinical Applications in Alzheimer's Disease

Issue title: Imaging the Alzheimer Brain

Guest editors: J. Wesson Ashford, Allyson Rosen, Maheen Adamson, Peter Bayley, Osama Sabri, Ansgar Furst, Sandra E. Black and Michael Weiner

Article type: Research Article

Authors: Oishi, Kenichi^{a; *} | Mielke, Michelle M.^b | Albert, Marilyn^c | Lyketsos, Constantine G.^b | Mori, Susumu^{a; d}

Affiliations: [a] The Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine, The Johns Hopkins University Baltimore, MD, USA | [b] Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA | [c] Department of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA | [d] F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA

Correspondence: [*] Correspondence to: Kenichi Oishi, MD, PhD, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA. Work: 410 502 3553; E-mail: [email protected].

Abstract: DTI is one of the most effective MR tools for the investigation of the brain anatomy. In addition to the gray matter, histopathological studies indicate that white matter is also a good target for both the early diagnosis of AD and for monitoring disease progression, which motivates us to use DTI to study AD patients in vivo. There are already a large amount of studies reporting significant differences between AD patients and controls, as well as to predict progression of disease in symptomatic non-demented individuals. Application of these findings in clinical practice remains to be demonstrated.

Keywords: Alzheimer's disease, mild cognitive impairment, white matter, diffusion tensor imaging, clinical application

DOI: 10.3233/JAD-2011-0007

Journal: Journal of Alzheimer's Disease, vol. 26, no. s3, pp. 287-296, 2011