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Bursting Dense Microspheres (Spherons) in Alzheimer's Disease

Subtitle: A Review of Studies (1980-1997) on Spherons and the Pathogenesis of Alzheimer's Disease

Article type: Research Article

Authors: Averback, Paula | Morse, Davidb | Ghanbari, Hosseina

Affiliations: [a] Nymox Corporation, 5516 Nicholson Lane, Suite 100A, Rockville, MD 20895, USA | [b] Biology Department, University of Montreal, 4101 Sherbrooke East, Montreal, Quebec, Canada H1X 2B2

DOI: 10.3233/JAD-1998-1101

Journal: Journal of Alzheimer's Disease, vol. 1, no. 1, pp. 1-34, 1998

Published: 1 April 1998
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Abstract

This paper reviews our research studies during the past 17 years on the relationship of cerebral protein dense microspheres (DMS), termed spherons, and senile plaques (SP) in the aged human brain and in AD. Initially, correlative anatomical and pathological data suggested that spherons may evolve into SP. This led to morphometric studies which strongly supported the theory. Biochemical studies were undertaken which showed that spherons could be isolated to homogeneity from brain tissue and contained the markers associated with SP. Experiments in vitro with spherons, and with inoculation of spherons into animals, reproduced SP lesion characteristics. To test the validity of using spherons for drug screening, experimental drugs were tested, a few of which are capable of blocking the formation of spheron-induced experimental SP.

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