Affiliations: Department of Pathology, Tokai University, Oiso
Hospital 21-1 Gakkyo, Oiso-Machi, Naka-Gun, Kanagawa 259-0198, JAPAN | Department of Internal Medicine, Tokai University,
Oiso Hospital 21-1 Gakkyo, Oiso-Machi, Naka-Gun, Kanagawa 259-0198, JAPAN
Note: [] Address for correspondence: Shinkichi Sato, MD, PhD Department
of Pathology Tokai University Oiso Hospital 21-1 Gakkyo, Oiso-Machi Naka-Gun,
Kanagawa 259-0198 JAPAN
Note: []
Abstract: An autopsy case of a primary hepatic leiomyosarcoma, a rare
malignancy in the liver, in a 62 year old female is documented with
immunohistochemical investigation. The tumor measured 24 x 20 x 18 cm in the
left lobe with multiple intrahepatic and distant metastases. Microscopically,
the tumor was accompanied by massive coagulative necrosis. Remaining viable
tumor tissue was mainly composed of two different lesions, a well to moderately
differentiated leiomyosarcoma and a poorly differentiated, anaplastic lesion.
Focal myxoid change was also identified. Well to moderately differentiated
tumor cells were positive for smooth muscle actin and vimentin
immunohistochemically. Those two histologically different tumors had their own
metastatic foci in the lungs and other organs. A brief review of the literature
is presented.
