SIGNAL TRANSDUCTION AND AGING

Article type: Research Article

Authors: Benguria, Alberto

Affiliations:

Note: [] Address for correspondence: Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, 1901 Perdido Street, New Orleans 70112, USA

Abstract: Aging research is entering in an exciting moment due to the identification of genes and pathways that modulate this process. This has been elucidated in lower eukaryotic organisms, mainly in yeast and in the nematode Caenorhabditis elegans. These studies have suggested that metabolic capacity, efficiency of stress responses and genetic regulation play an important role in determining life span, and signal transduction pathways clearly regulate these processes. Similar pathways exist in mammals and some of them might also regulate their pace of aging.

Keywords: Aging, nematodes, yeast, Drosophila melanogaster, growth factor

Journal: Electronic Journal of Pathology and Histology, vol. 6, no. 1, pp. 04-04, 2000