Affiliations: Department of Medical Biochemistry, College of
Medicine, Qassim University, Qassim, KSA | Department of Dermatology, College of Medicine, Qassim
University, Qassim, KSA
Note: [] Corresponding author: Ragaa H.M. Salama, Medical Biochemistry, Kingdom of Saudi Arabia, Qassim, Qassim University,
Collage of Medicine, P.O 6655, Buraidah: 51452, Female section. Permanent
address: Medical Biochemistry Department, Faculty of Medicine, Assuit
University, Assiut, Egypt. Tel.: +966 3800050 ext-6043; Fax: +966 3802082;
E-mail: [email protected]
Abstract: To evaluate the role of psoriasin, koebnerisin, interleukn (IL)-12
and IL-23 in the pathogenesis of psoriasis and their relations to Psoriasis
Area Severity Index (PASI) and obesity. Thirty patients had chronic plaque
psoriasis and 30 healthy subjects matched in age and sex were enrolled in this
study. Serum from all subjects were used for determination of psoriasin,
koebnerisin, IL-12 and IL-23 by ELISA kits. IL-23 and psoriasin were
significantly higher in skin psoriasis compared to controls and psoriatic
arthritis (PsA). There was a correlation between psoriasin and both PASI and
obesity. On the other hand, IL-12 was significantly increased in PsA compared
to skin psoriasis (p=0.000) and controls. Its sensitivity and specificity were
87%, 93%; respectively. To our knowledge, psoriasin is the first biomarker
confirm the link between obesity and psoriasis. The risk of developing
psoriasis is directly related to higher BMI.}
