Affiliations: Endocrinology and Metabolism Research Center, Tehran
University of Medical Sciences, Tehran, Iran | Department of Medical Genetics, School of Medicine,
Tehran University of Medical Sciences, Tehran, Iran | Department of Epidemiology and Biostatistics, School
of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Note: [] Corresponding authors: Mahsa M. Amoli, Dr Shariati
Hospital, North Karegar St., Tehran 14114, Iran. Tel.: +98 21 88220037-8; Fax:
+98 21 88220052; E-mail: amolimm@tums. ac.ir. and Javad Tavakkoly Bazzaz,
Department of Medical Genetics, Tehran University of Medical Sciences, Poursina
St., Tehran, 14176, Iran. Tel./Fax: +98 21 88953005; E-mail:
[email protected]
Abstract: Objective: Both adaptive and innate immune systems are involved in
coronary artery disease (CAD). The aim of this study was to evaluate TH17
cytokines expression profiles in un-stimulated peripheral blood lymphocytes
(PBMCs) of patients with coronary artery disease. Methods: Expression profiles of IL-17, IL-23, and TGF-β1 were
determined in individuals with and without CAD using Real-time PCR. Results: A significant decrease in IL-23 gene expression in
un-stimulated PBMCs of patients with CAD compared to those without CAD was
found (p=0.003, OR=0.045, 95% CI: 0.006–0.355). Conclusion: Our data reinforce the potential role of the IL-23 as a
critical regulatory molecule that bridges the innate and adaptive arms of the
immune system in the complex mechanisms associated with the development of
atherosclerosis.
