Cancer biomarker discovery: Lectin-based strategies targeting glycoproteins

Article type: Research Article

Authors: Clark, David | Mao, Li

Affiliations: Department of Oncology and Diagnostic Sciences, University of Maryland, School of Dentistry, Baltimore, MD, USA

Note: [] Corresponding author: Li Mao, MD, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA. E-mail: [email protected]

Abstract: Biomarker discovery can identify molecular markers in various cancers that can be used for detection, screening, diagnosis, and monitoring of disease progression. Lectin-affinity is a technique that can be used for the enrichment of glycoproteins from a complex sample, facilitating the discovery of novel cancer biomarkers associated with a disease state.

Keywords: Lectins, lectin-affinity, biomarkers, glycosylation, glycoproteins

DOI: 10.3233/DMA-2012-0904

Journal: Disease Markers, vol. 33, no. 1, pp. 1-10, 2012